Results 81 to 90 of about 4,756 (186)

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source

ADAMTS1 Is a Unique Hypoxic Early Response Gene Expressed by Endothelial Cells [PDF]

Journal of Biological Chemistry, 2009
ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is a member of the matrix metalloproteinase family. We have previously reported that ADAMTS1 was strongly expressed in myocardial infarction. In this study, we investigated whether hypoxia induced ADAMTS1 and investigated its regulatory mechanism.
Omer F, Hatipoglu, Satoshi, Hirohata, M Zeynel, Cilek, Hiroko, Ogawa, Toru, Miyoshi, Masanari, Obika, Kadir, Demircan, Ryoko, Shinohata, Shozo, Kusachi, Yoshifumi, Ninomiya   +9 more
openaire   +2 more sources

Aging Impairs Macrophage Phagocytosis Through Mitochondrial ROS‐Induced Collagen Production

Aging Cell, Volume 25, Issue 6, June 2026.
Aging compromises macrophage phagocytosis via the mitochondrial ROS‐driven overproduction of intracellular collagen. This excess collagen physically binds F‐actin, paralyzing cytoskeletal turnover; however, mtROS scavenging successfully rescues actin dynamics and restores phagocytic capacity.
Yuming Wang, Xin Xu, Nuanqin Shen, Ping Han, Liuyi Wu, Yi Jin, Yiming Sun, Lanlan Xiao, Jinyou Li, Lan Wang, Yunmei Yang, Qin Zhang, Weiqian Chen, Chaohui Yu, Bowen Wu   +14 more
wiley   +1 more source

haemoreologic aspects of regulation of expression of angiogenesis modulating factors ADAMTS1, Angiopoietin-2 and Interleukin-8

, 2013
Ziel dieser Arbeit war die Untersuchung der strömungsabhängigen Expressionsregulation des antiangiogenen Faktors ADAMTS1 und des angiogenen Faktors Angiopoietin-2 in Endothelzellen in vitro und in vivo.
Hohberg, Margret
core   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells [PDF]

European Cells & Materials, 2012
Aggrecanases from the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family are important therapeutic targets due to their essential role in aggrecan depletion in arthritic diseases.
W Richter, B Moradi, CB Little, J Fischer, S Boeuf, F Graf   +5 more
doaj  

Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer’s Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Maternal choline supplementation (MCS) is utilized in the Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD). At ~6 months of age, laser capture microdissection and single population RNA‐sequencing of three hippocampal neuron populations (CA1 and CA3 pyramidal neurons and dentate gyrus granule cells) were conducted.
Melissa J. Alldred, Kyrillos W. Ibrahim, Harshitha Pidikiti, Sang Han Lee, Adriana Heguy, Gabriela Chiosis, Elliott J. Mufson, Grace E. Stutzmann, Stephen D. Ginsberg   +8 more
wiley   +1 more source

Early Diagnosis of Pancreatic Cancer: The Key for Survival

Diagnostics, 2020
Pancreatic cancer (PC) is one of the most aggressive forms of cancer. Negative prognosis is mainly due to the late diagnosis in advanced stages, when the disease is already therapeutically overcome.
Gina Gheorghe, Simona Bungau, Madalina Ilie, Tapan Behl, Cosmin Mihai Vesa, Ciprian Brisc, Nicolae Bacalbasa, Vladiana Turi, Raluca Simona Costache, Camelia Cristina Diaconu   +9 more
doaj   +1 more source

Use of anti–amyloid‐β monoclonal antibodies in persons with Down syndrome Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The recent development and licensing of anti–amyloid‐β monoclonal antibodies for the treatment of early‐stage Alzheimer's disease have significantly shifted the clinical landscape. However, current use recommendations preclude the administration of these new drugs to persons who have Down syndrome.
Clíona Farrell, Fedal Saini, Mona M. Beidas, Natalie S. Ryan, Andre Strydom, Frances K. Wiseman   +5 more
wiley   +1 more source

Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao, Hangyu Shen, Xu Yan, Xiang Gao, Yuchun Liu, Shengjun Zhou, Jingxian Sun, Jie Sun, Yi Huang   +8 more
wiley   +1 more source