Results 71 to 80 of about 4,756 (186)

ADAMTS-1 Is Found in the Nuclei of Normal and Tumoral Breast Cells. [PDF]

PLoS ONE, 2016
Proteins secreted in the extracellular matrix microenvironment (ECM) by tumor cells are involved in cell adhesion, motility, intercellular communication and invasion.
Suély V Silva, Maíra A Lima, Nathalie Cella, Ruy G Jaeger, Vanessa M Freitas   +4 more
doaj   +1 more source

Rapamycin Partially Reverts Cavernoma Endothelial Cell Phenotype and, When Combined With Lapatinib, Ameliorates Chronic Lesions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT This study investigates the impact of rapamycin and propranolol on cerebral cavernous malformations (CCMs). Employing an unbiased transcriptomic analysis, we aimed to comprehensively elucidate the molecular mechanisms underlying these drug effects.
Mar García‐Colomer, José E. Martínez, Luis Díaz‐Gómez, Miriam Sartages, Eva M. Esquinas‐Román, Cristina Riobello, David Martínez‐Delgado, Diego González‐Pérez, Aurora Gómez‐Durán, Miguel Fidalgo, Marta Varela‐Rey, Celia M. Pombo, Juan Zalvide   +12 more
wiley   +1 more source

505. THE ROLE OF Adamts1 IN BREAST CANCER PROGRESSION AND METASTASIS

, 2009
The extracellular protease Adamts1 is a vital enzyme involved in normal development and has been associated with various processes of extracellular matrix (ECM) remodelling including ovulation and pathologies exhibiting disrupted ECM.
C. Ricciardelli, D. L. Russell, K. M. Frewin, I. A. Tan   +3 more
core   +1 more source

Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF‐κB and STAT3 pathways in osteosarcoma

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract Osteosarcoma (OS) is an aggressive bone malignancy characterized by genomic instability and extensive extracellular matrix (ECM) remodeling. Members of the ADAMTS family are matrix‐associated proteases implicated in tumorigenesis; however, their roles in OS remain poorly defined. This study provides a comprehensive genomic, transcriptomic, and
Ehed Muhammed Aymaz, Meltem Alper, Feyza Nur Sav, Tuğşen Aydemir, Feray Köçkar   +4 more
wiley   +1 more source

ADAMTS1 secreted from stromal fibroblasts enhanced cancer cell invasion.

, 2012
(A) Sequestration of the ADAMTS1 activity in the conditional medium derived from CAF 199C.P10 using an anti-ADAMTS1 antibody reduced invasion ability of MDA-MB-468 cells (left) and MDA-MB-231 cells (right) in an anti-ADAMTS1 Ab dose-dependent manner. (B)
Li-Jung Juan (171247), Chih-Hung Hsu (171225), Kai-Lin Peng (171228), Jin-Yuh Shew (171239), Eva Y.-H. P. Lee (171236), King-Jen Chang (132031), Wen-Hwa Lee (171250), Wen-Hung Kuo (132019), Chun-Chin Chen (171232), Shiaw-Wei Tyan (171220)   +9 more
core   +1 more source

Gene Expression and Immunochemistry Analysis of ADAMTS-1 and Versican in Ameloblastoma

International Journal of Dentistry, 2022
Background. Ameloblastoma is a benign but locally invasive odontogenic epithelial tumor, associated with a high recurrence rate after treatment. The action of enzymes of the metalloproteinase family is important to the degraded extracellular matrix ...
Osvaldo Rodrigues de Souza Neto, Hellen Thais Fuzii, Suély Vieira Da Silva, Vanessa Morais Freitas, João de Jesus Viana Pinheiro   +4 more
doaj   +1 more source

Sensing and Communicating β‐Cell Stress in the Context of T1D Etiology: New Opportunities for Therapeutic Impact

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Type 1 diabetes (T1D) results from the immune‐mediated destruction of insulin‐producing pancreatic β‐cells. Recent human studies show that early β‐cell stress maladaptations precede overt immune cell infiltration. DOC2B, a vesicle secretion regulatory protein that supports β‐cell functionality and resilience against stress, declines early in T1D ...
Diana Esparza, Chathurani S. Jayasena, Tijana Jovanovic‐Talisman, Debbie C. Thurmond   +3 more
wiley   +1 more source

Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers

Molecular Cancer, 2008
Background Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact. This study aims to pinpoint epigenetic markers that can discriminate between non-malignant and malignant tissue from the ...
Vatn Morten, Meling Gunn I, Costa Vera L, Lind Guro E, Ahlquist Terje, Hoff Geir S, Rognum Torleiv O, Skotheim Rolf I, Thiis-Evensen Espen, Lothe Ragnhild A   +9 more
doaj   +1 more source

Collagen III Deficiency Following Injury in Female Murine Tendons Alters Matrix Composition, Structure, Organization and Function

Journal of Orthopaedic Research, Volume 44, Issue 6, June 2026.
ABSTRACT Tendons withstand large forces due to an aligned, dense collagen matrix. However, their low cellularity and relative inability to recruit reparative cells post‐injury, coupled with a susceptibility to excessive scarring results in loss of tendon structure and function. Type III collagen (COL3) plays a key role in regulating matrix architecture
J. A. Carlson, W. Yen, S. N. Weiss, S. W. Volk, L. J. Soslowsky   +4 more
wiley   +1 more source

ADAMTS1, CRABP1, and NR3C1 Identified as Epigenetically Deregulated Genes in Colorectal Tumorigenesis

Cellular Oncology, 2006
Background: Gene silencing through CpG island hypermethylation is a major mechanism in cancer development. In the present study, we aimed to identify and validate novel target genes inactivated through promoter hypermethylation in colorectal tumor ...
Guro E. Lind, Kristine Kleivi, Gunn I. Meling, Manuel R. Teixeira, Espen Thiis-Evensen, Torleiv O. Rognum, Ragnhild A. Lothe   +6 more
doaj   +1 more source