Results 51 to 60 of about 4,756 (186)

Pericyte TIMP3 and ADAMTS1 Modulate Vascular Stability after Kidney Injury [PDF]

Journal of the American Society of Nephrology, 2012
Kidney pericytes are progenitors of scar-forming interstitial myofibroblasts that appear after injury. The function of kidney pericytes as microvascular cells and how these cells detach from peritubular capillaries and migrate to the interstitial space, however, are poorly understood.
Claudia, Schrimpf, Cuiyan, Xin, Gabriella, Campanholle, Sean E, Gill, William, Stallcup, Shuei-Liong, Lin, George E, Davis, Sina A, Gharib, Benjamin D, Humphreys, Jeremy S, Duffield   +9 more
openaire   +2 more sources

Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries

, 2010
ADAMTS1 inhibits capillary sprouting, and since capillary sprouts do not experience the shear stress caused by blood flow, this study undertook to clarify the relationship between shear stress and ADAMTS1.
Hoffmann, Christian J, Mauro Bongrazio, Beata Styp-Rekowska, Wunderlich, Wulf, Knudsen, Rose, Fiedorowicz, Katarzyna, Maroski, Julian, Sven Chlench, Vorderwülbecke, Bernd J, Lehmann, Robert, Michael Hoepfner, Bernd J. Vorderwülbecke, Axel R. Pries, Robert Lehmann, Luis Da Silva-Azevedo, Pries, Axel R, Chlench, Sven, Katarzyna Fiedorowicz, Hohberg, Margret, Christian J. Hoffmann, Knöchel, Judith, Rose Knudsen, Da Silva-Azevedo, Luis, Judith Knöchel, Julian Maroski, Bongrazio, Mauro, Alexander Alter, Alter, Alexander, Zakrzewicz, Andreas, Margret Hohberg, Nitsche, Bianca, Styp-Rekowska, Beata, Wulf Wunderlich, Hoepfner, Michael, Bianca Nitsche, Andreas Zakrzewicz   +35 more
core   +1 more source

Curcuma longa and Boswellia serrata Extracts Modulate Different and Complementary Pathways on Human Chondrocytes In Vitro: Deciphering of a Transcriptomic Study

Frontiers in Pharmacology, 2022
Objectives:Curcuma longa (CL) and Boswellia serrata (BS) extracts are used to relieve osteoarthritis symptoms. The aim of this in vitro study was to investigate their mechanisms of action at therapeutic plasmatic concentrations on primary human ...
Christelle Sanchez, Christelle Sanchez, Jérémie Zappia, Jérémie Zappia, Cécile Lambert, Cécile Lambert, Jacques Foguenne, Yvan Dierckxsens, Jean-Emile Dubuc, Jean-Emile Dubuc, Jean-Pierre Delcour, André Gothot, Yves Henrotin, Yves Henrotin, Yves Henrotin   +14 more
doaj   +1 more source

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis [PDF]

Developmental Cell, 2008
Developing myocardial cells respond to signals from the endocardial layer to form a network of trabeculae that characterize the ventricles of the vertebrate heart. Abnormal myocardial trabeculation results in specific cardiomyopathies in humans and yet trabecular development is poorly understood.
Stankunas, Kryn, Hang, Calvin T., Tsun, Zhi-Yang, Chen, Hanying, Lee, Nathan V., Wu, Jiang I., Shang, Ching, Bayle, J. Henri, Shou, Weinian, Iruela-Arispe, M. Luisa, Chang, Ching-Pin   +10 more
openaire   +2 more sources

Single‐cell RNA sequencing reveals a mechanism underlying the susceptibility of the left atrial appendage to intracardiac thrombogenesis during atrial fibrillation

Clinical and Translational Medicine, 2023
Background Atrial fibrillation (AF) is associated with an increased risk of thrombosis of the left atrial appendage (LAA). However, the molecular mechanisms underlying this site‐specificity remain poorly understood.
Jie Yang, Hu Tan, Mengjia Sun, Renzheng Chen, Zhao Jian, Yuanbin Song, Jihang Zhang, Shizhu Bian, Bo Zhang, Yi Zhang, Xubin Gao, Zhen Chen, Boji Wu, Xiaowei Ye, Hailin Lv, Zhen Liu, Lan Huang   +16 more
doaj   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

The Cleavage of Semaphorin 3C Induced by ADAMTS1 Promotes Cell Migration [PDF]

Journal of Biological Chemistry, 2010
Metastasis is a sequential process that allows cells to move from the primary tumor and grow elsewhere. Because of their ability to cleave a variety of extracellular signaling and adhesion molecules, metalloproteases have been long considered key components of the metastatic program.
Cary, Esselens, Jordi, Malapeira, Núria, Colomé, Carmen, Casal, Juan Carlos, Rodríguez-Manzaneque, Francesc, Canals, Joaquín, Arribas   +6 more
openaire   +2 more sources

The role of serum ADAMTS-1 levels in Hyperemesis Gravidarum

BMC Pregnancy and Childbirth, 2022
Background We aimed to investigate the levels of ADAMTS-1, which is secreted from the extracellular matrix during trophoblastic invasion in hyperemesis gravidarum (HEG).
Burcu Timur, Gurhan Guney
doaj   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source