Results 41 to 50 of about 4,756 (186)

Identification of polyunsaturated fatty acids related key modules and genes in metabolic dysfunction-associated fatty liver disease using WGCNA analysis

Frontiers in Genetics, 2022
Polyunsaturated fatty acids (PUFAs) play important roles in the aetiology and pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD). However, the underlying molecular mechanisms are not understood. We analysed a public GEO dataset,
Cheng Xiao, Siliang Chen, Siliang Chen, Chunru Yang, Jieying Liu, Jieying Liu, Miao Yu   +6 more
doaj   +1 more source

Screening target genes for the treatment of PCOS via analysis of single-cell sequencing data

Annals of Medicine, 2022
Background Polycystic ovary syndrome (PCOS) is a condition of the female reproductive system and it remains imperative to identify target genes responsible for its pathogenesis and develop therapeutic drugs capable of effectively treating it.Methods We ...
Zhenzhen Lu, Chunyan Chen, Ying Gao, Yanhui Li, Xiaojie Zhao, Hanke Zhang, Qiongqiong Wei, Xinliu Zeng, Yajie Li, Min Wan   +9 more
doaj   +1 more source

ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2 [PDF]

The EMBO Journal, 2006
Matrix metalloproteases regulate both physiological and pathological events by processing matrix proteins and growth factors. ADAMTS1 in particular is required for normal ovulation and renal function and has been shown to modulate angiogenesis. Here we report that TSP1 and 2 are substrates of ADAMTS1.
Nathan V, Lee, Makoto, Sato, Douglas S, Annis, Joseph A, Loo, Lily, Wu, Deane F, Mosher, M Luisa, Iruela-Arispe   +6 more
openaire   +2 more sources

Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms

Clinical Epigenetics, 2023
Background Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge.
Ankit Chhoda, Anup Sharma, Bethsebie Sailo, Haoyu Tang, Nensi Ruzgar, Wan Ying Tan, Lee Ying, Rishabh Khatri, Anand Narayanan, Shrikant Mane, Bony De Kumar, Laura D. Wood, Christine Iacobuzio-Donahue, Christopher L. Wolfgang, John W. Kunstman, Ronald R. Salem, James J. Farrell, Nita Ahuja   +17 more
doaj   +1 more source

食管癌组织中ADAMTS1、ADAMTS18基因mRNA的表达及其意义

Zhongguo shiyan zhenduanxue, 2021
目的探讨ADAMTS1和ADAMTS18基因在食管鳞状细胞癌组织中的表达及其与食管鳞状细胞癌临床病理特征的关系。方法应用半定量逆转录聚合酶链反应(RT-PCR)方法分别检测70例食管鳞状细胞癌组织及癌旁正常组织中ADAMTS1、ADAMTS18的mRNA表达,并分析基因表达与临床病理资料之间的关系。结果食管鳞状细胞癌组织中ADAMTS1、ADAMTS18基因的mRNA表达水平显著低于相应的癌旁正常组织(P0.05),ADAMTS1基因mRNA在有淋巴结转移组的表达量高于无淋巴结转移组(P0.05 ...
尹蕾, 郭丽丽, 郭炜, 任郁英, 秦志梅, 赵素斌   +5 more
doaj  

Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

Clinical Epigenetics, 2019
Background Despite improvements in cancer management, most pancreatic cancers are still diagnosed at an advanced stage. We have recently identified promoter DNA methylation of the genes ADAMTS1 and BNC1 as potential blood biomarkers of pancreas cancer ...
Maryam A. L. Eissa, Lane Lerner, Eihab Abdelfatah, Nakul Shankar, Joseph K. Canner, Nesrin M. Hasan, Vesal Yaghoobi, Barry Huang, Zachary Kerner, Felipe Takaesu, Christopher Wolfgang, Ruby Kwak, Michael Ruiz, Matthew Tam, Thomas R. Pisanic, Christine A. Iacobuzio-Donahue, Ralph H. Hruban, Jin He, Tza-Huei Wang, Laura D. Wood, Anup Sharma, Nita Ahuja   +21 more
doaj   +1 more source

Prodigiosin Alleviates Pulmonary Fibrosis Through Inhibiting miRNA-410 and TGF-β1/ADAMTS-1 Signaling Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Pulmonary fibrosis is a common outcome of various interstitial lung diseases. Prodigiosin (PG) is a series of red pigment with methoxypyrrole ring.
Hao Liu, Yi He, Zhaolei Jiang, Saie Shen, Ju Mei, Min Tang   +5 more
doaj   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Differentially regulated ADAMTS1, 8, and 18 in gastric adenocarcinoma

Bratislava Medical Journal, 2017
The aim is to investigate the expression status of ADAMTS1,8, and 18 proteases in gastric cancer (GC) and lymphatic metastasis.A disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) is a new protease family, and has important biological functions such as hemostasis, extracellular matrix remodeling and regulation of angiogenesis.The ...
Kilic, M. O., Icen, D., Aynekin, B., Kara, A., Demircan, K.   +4 more
openaire   +5 more sources

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source