Results 21 to 30 of about 4,756 (186)

Adamts1 in vascular homeostasis and remodelling [PDF]

, 2015
Aneurysms involving the aortic root and the ascending aorta leading to dissections are the major diseases affecting the aorta and a common cause of premature deaths ranking as high as the XXth cause of death in developed countries. The major constituent of the vessel wall is the extracellular matrix (ECM).
Oller, Jorge, Mendez-Barbero, Nerea, Alberca, Rut, Lozano-Vidal, Noelia, Iturri, Lizet Sandra, Jimenez-Borreguero, Luis J., Arroyo, Alicia G, Campanero, Miguel R, Redondo, Juan Miguel   +8 more
core   +3 more sources

Androgen-Independent Prostate Cancer - studies on angiogenesis and ADAMTS1 [PDF]

, 2009
Androgen deprivation therapy (ADT) is the standard treatment for advanced prostate cancer since prostate tumors initially are dependent on androgens for growth. However, most tumors will eventually relapse and grow in a highly aggressive and androgen-independent (AI) manner.
Gustavsson, Heléne
core   +4 more sources

ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors

Biochemical and Biophysical Research Communications, 2002
ADAMTS1 is a secreted protein that belongs to the recently described ADAMTS (a disintegrin and metalloprotease with thrombospondin repeats) family of proteases. Evaluation of ADAMTS1 catalytic activity on a panel of extracellular matrix proteins showed a restrictive substrate specificity which includes some proteoglycans.
Juan Carlos, Rodríguez-Manzaneque, Jennifer, Westling, Shelley N-M, Thai, Alfonso, Luque, Vera, Knauper, Gillian, Murphy, John D, Sandy, M Luisa, Iruela-Arispe   +7 more
openaire   +3 more sources

ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Rocks, N, Cataldo, D
openaire   +4 more sources

Hereditary Thrombotic Thrombocytopenic Purpura Associated With Recurrent Strokes and Prominent Nervous System Involvement in a Young Chinese Female [PDF]

Clinical Case Reports
Hereditary thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive inherited disease caused by an ADAMTS1 gene mutation, resulting in absence or severe deficiency of plasma ADAMTS13 activity.
Wanying Liu, Jiaying Wu, Xi Ming, Qi Zhang, Delian Zhou, Rubing Zheng, Mi Zhou, Zhen Shang, Liting Chen, Xiaojian Zhu, Yi Xiao   +10 more
doaj   +2 more sources

Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk

Frontiers in Aging Neuroscience, 2022
Amyloid-β (Aβ) derived from amyloid precursor protein (APP) hydrolysis is acknowledged as the predominant hallmark of Alzheimer’s disease (AD) that especially correlates to genetics and daily activities.
Yunjie Qiu, Longze Sha, Longze Sha, Xiuneng Zhang, Guanjun Li, Wanwan Zhu, Wanwan Zhu, Qi Xu, Qi Xu   +8 more
doaj   +1 more source

Expression Level of ADAMTS1 in Granulosa Cells of PCOS Patients Is Related to Granulosa Cell Function, Oocyte Quality, and Embryo Development

Frontiers in Cell and Developmental Biology, 2021
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is an extracellular matrix metalloproteinase that plays an important role in the process of ovulation.
Guang Yang, Guang Yang, Guidong Yao, Guidong Yao, Ziwen Xu, Ziwen Xu, Huiying Fan, Huiying Fan, Xingui Liu, Xingui Liu, Jiahuan He, Jiahuan He, Yue Kong, Yue Kong, Deqi Kong, Deqi Kong, Yucheng Bai, Yucheng Bai, Qina He, Qina He, Tongwei Zhang, Tongwei Zhang, Junya Zhang, Junya Zhang, Yingpu Sun, Yingpu Sun   +25 more
doaj   +1 more source

Characterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5. [PDF]

J Biol Chem
A Disintegrin-like And Metalloprotease domain with Thrombospondin type I motifs (ADAMTS) 9 has essential, non-redundant roles during embryogenesis. Adamts9 null murine embryos die prior to completing gastrulation. Unusually, for a protease, Adamts9 haploinsufficiency results in cardiovascular and ocular anomalies.
Martin DR, Sardelli G, Burkhard T, Fowkes MM, Minns AF, Moschini R, Del Corso A, de Groot R, Apte SS, Santamaria S.   +9 more
europepmc   +5 more sources

Adamts1 responds to systemic cues and gates adipogenesis [PDF]

Adipocyte, 2017
Intuitively, excess caloric intake causes adipose tissue expansion. However, the signals and mechanisms by which this systemic trigger directs a local response in the adipose tissue are incompletely understood. Both hypertrophy of existing adipocytes and the generation of new adipocytes through differentiation of adipocyte precursor cells (APCs ...
Wong, Janica C, Feldman, Brian J
openaire   +4 more sources

Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis [PDF]

, 2012
Angiogenesis plays an important role in tumor progression. Several reports have demonstrated that a disintegrin and metalloproteinase with thrombospondin motifs1 (ADAMTS1) inhibited angiogenesis via multiple mechanisms.
Inagaki, Junko, Ninomiya, Yoshifumi, Obika, Masanari, Ohtsuki, Takashi, Hatipoglu, Omer Faruk, Cilek, Mehmet Zeynel, Hirohata, Satoshi, Miyoshi, Toru, Li, Jiayi, Takahashi, Katsuyuki, Ogawa, Hiroko, Kusachi, Shozo   +11 more
core   +2 more sources