Enhanced expression of ADAMTS1 in ovarian carcinomas: loss of ADAMTS1 expression instigates cellular reprogramming of extracellular matrix ensuing altered plasticity, augmented migration and attenuated adhesion [PDF]
Journal of Biomedical ScienceBackground ADAMTS1, a disintegrin and metalloproteinase with thrombospondin motif 1, plays a role in inflammation, organogenesis, and ovulation. Up or downregulation of ADAMTS1 has been implicated in tissue remodelling leading to cancer.
Ruth M. Escalona +6 more
doaj +2 more sources
Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8 [PDF]
Advanced Science‐Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, with post‐infarction cardiac remodeling, particularly excessive scar formation, representing a critical determinant of patient outcomes.
Chun‐Yan Kong +11 more
doaj +2 more sources
The Dual Role of ADAMTS1 in Cardiovascular Remodeling: Balancing Extracellular Matrix Homeostasis and Pathological States [PDF]
Journal of Cardiovascular Development and DiseaseExtracellular matrix metalloproteinase ADAMTS1 (adhesion metalloproteinase with thrombospondin-type domain 1) is a key regulator in cardiovascular remodeling with functional paradoxes.
Siqin Sheng, Shunrong Zhang
doaj +2 more sources
Transcriptome Analysis Reveals the Molecular Mechanisms by Which ADAMTS1 Influences the Proliferation of Ovarian Granulosa Cells in Sheep [PDF]
AnimalsNormal proliferation of ovarian granulosa cells is essential for follicular development. The results of this study showed that ADAMTS1 was primarily localized in the cytoplasm of granulosa cells in sheep ovarian follicles, as revealed by ...
Rongqing Li +12 more
doaj +2 more sources
Biology, 2022 Lung adenocarcinoma (LUAD) still holds the most dreadful clinical outcomes worldwide. Despite advanced treatment strategies, there are still some unmet needs.
Hsiao-Chen Lee +2 more
exaly +3 more sources
Deciphering the regulatory mechanism and therapeutic potential of ECM degradation in intervertebral disc degeneration via multi-omics integration [PDF]
Frontiers in ImmunologyBackgroundIntervertebral disc degeneration (IVDD) is a major cause of chronic low back pain, characterized not only by extracellular matrix (ECM) degradation but also by a chronic low-grade inflammatory response.
Lei Feng +4 more
doaj +2 more sources
Glomerular Transcriptome Analysis Reveals Endothelial Disturbances in Patients With Idiopathic Nephrotic Syndrome [PDF]
Kidney MedicineRationale & Objective: Idiopathic nephrotic syndrome (INS) is viewed as a podocyte-specific disease. Recent reports indicate endothelial involvement, but its significance is unclear.
Sarah K. Nelson-Taylor +19 more
doaj +2 more sources
Proteolytic remodelling of the extracellular matrix by pericytes. [PDF]
FEBS JPericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Burkhard T +4 more
europepmc +2 more sources
Fluorescence Resonance Energy Transfer Assay for High-Throughput Screening of ADAMTS1 Inhibitors
Molecules, 2011 A disintegrin and metalloprotease with thrombospondin type I motifs-1 (ADAMTS1) plays a crucial role in inflammatory joint diseases and its inhibitors are potential candidates for anti-arthritis drugs.
Lili Gong, Du Guanhua
exaly +3 more sources
The oncogenic ADAMTS1–VCAN–EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma [PDF]
Cellular & Molecular Biology LettersBackground Metastasis, the leading cause of renal cell carcinoma (RCC) mortality, involves cancer cells resisting anoikis and invading. Until now, the role of the matrix metalloproteinase (MMP)-related enzyme, A disintegrin and metalloprotease with ...
Yu-Ching Wen +8 more
doaj +2 more sources