Differentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma [PDF]
Gastroenterology Review, 2017 Introduction : Despite recent diagnostic and therapeutic improvements, pancreas cancer remains one of the highly lethal cancers. The extracellular matrix (ECM) is a physiological barrier that limits the spread of cancer cells into surrounding tissues and
Murat Özgür Kılıç +6 more
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Macrophage-released ADAMTS1 promotes muscle stem cell activation [PDF]
Nature Communications, 2017 Satellite cells are crucial for growth and regeneration of skeletal muscle. Here the authors show that in response to muscle injury, macrophages secrete Adamts1, which induces satellite cell activation by modulating Notch1 signaling.
Hongqing Du +7 more
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ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1
Cell & Bioscience, 2023 Background ISGylation is a post-translational protein modification that regulates many life activities, including immunomodulation, antiviral responses, and embryo implantation.
Yaru Chen +9 more
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ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors [PDF]
BMC Cancer, 2010 Background Decreased expression of the angiogenesis inhibitor ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) has previously been reported during prostate cancer progression.
Damber Jan-Erik +5 more
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Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change. [PDF]
PLoS ONE, 2012 Microenvironment plays an important role in cancer development. We have reported that the cancer-associated stromal cells exhibit phenotypic and functional changes compared to stromal cells neighboring to normal tissues. However, the molecular mechanisms
Shiaw-Wei Tyan +9 more
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The ADAMTS1 Protease Gene Is Required for Mammary Tumor Growth and Metastasis [PDF]
The American Journal of Pathology, 2011 A disintegrin and metalloprotease with thrombospondin motifs protein 1 (ADAMTS1) is a protease commonly up-regulated in metastatic carcinoma. Its overexpression in cancer cells promotes experimental metastasis, but whether ADAMTS1 is essential for metastatic progression is unknown.
Ricciardelli, Carmela +7 more
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The 3'-untranslated region of ADAMTS1 regulates its mRNA stability. [PDF]
Acta medica Okayama, 2009 ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is an inflammatory-induced gene. We have previously reported that ADAMTS1 was strongly but transiently expressed in the infarcted heart. In this study, we investigated whether a 3'-untranslated region (UTR) affects the mRNA stability of this gene.
Hatipoglu, Omer Faruk +9 more
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Role of ADAMTS1 and ADAMTS5 in male infertility
Andrologia, 2016 The aim of this study was to investigate the relationship of infertility with metalloproteinases ADAMTS1 and ADAMTS5, which are known to be responsible for the degradation of extracellular matrix (ECM) proteins associated with many diseases. ECM is the noncellular component that provides structural and biochemical support to the surrounding cells ...
Aydos, S. E. +4 more
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Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1. [PDF]
PLoS ONE, 2012 The chondroitin sulfate-bearing proteoglycans, also known as lecticans, are a major component of the extracellular matrix (ECM) in the central nervous system and regulate neural plasticity.
Matthew D Howell +3 more
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Loss of the extracellular protease ADAMTS1 reveals an antitumorigenic program involving the action of NIDOGEN-1 on macrophage polarization [PDF]
OncoImmunologyRecent research highlighted the contribution of extracellular matrix, and particularly of ADAMTS proteases, in immune regulation. Now, our work with melanoma and mammary tumor models revealed that tumor blockade induced by the lack of Adamts1 led to an ...
Rita Caracuel-Peramos +12 more
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