Results 31 to 40 of about 4,756 (186)

Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity

Antioxidants, 2023
Atherosclerosis is a chronic inflammatory disease and a leading cause of mortality. It is characterized by arterial wall plaques that contain high levels of cholesterol and other lipids and activated leukocytes covered by a fibrous cap of extracellular ...
Yihe Wang, Astrid Hammer, Gerald Hoefler, Ernst Malle, Clare L. Hawkins, Christine Y. Chuang, Michael J. Davies   +6 more
doaj   +1 more source

Effects of insulin-like growth factor-induced Wharton jelly mesenchymal stem cells toward chondrogenesis in an osteoarthritis model [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): This study aimed to determine the collagen type II (COL2) and SOX9 expression in interleukin growth factor (IGF-1)-induced Wharton’s Jelly mesenchymal stem cells (WJMSCs) and the level of chondrogenic markers in co-culture IGF1-WJMSCs and ...
Wahyu Widowati, Ervi Afifah, Tjandrawati Mozef, Ferry Sandra, Rizal Rizal, Annisa Amalia, Yukko Arinta, Indra Bachtiar, Harry Murti   +8 more
doaj   +1 more source

Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion [PDF]

The International Journal of Biochemistry & Cell Biology, 2009
Syndecan-4 is a membrane-bound heparan sulfate proteoglycan that participates in cell-cell and cell-matrix interactions and modulates adhesion and migration of many cell types. Through its extracellular domain, syndecan-4 cooperates with adhesion molecules and binds matrix components relevant for cell migration.
Juan Carlos, Rodríguez-Manzaneque, Darren, Carpizo, María del Carmen, Plaza-Calonge, Antoni Xavier, Torres-Collado, Shelley N-M, Thai, Michael, Simons, Arie, Horowitz, M Luisa, Iruela-Arispe   +7 more
openaire   +2 more sources

Adamts1 and Cyst Expansion in Polycystic Kidney Disease. [PDF]

J Am Soc Nephrol
Key Points Adamts1 mRNA expression in the kidney was increased with loss of Pkd1, leading to cleavage of V1 isoform of versican in the tubular basement membrane.Increased versican cleavage promoted peritubular accumulation and activation of macrophages.
Kakade VR, Akman Z, Motrapu M, Cassini MF, Xu L, Moeckel G, Somlo S, Cantley LG.   +7 more
europepmc   +3 more sources

PGF_2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer

BMC Cancer, 2010
Background An increase in cancer cell invasion and microvascular density is associated with a poorer prognosis for patients with endometrial cancer. In endometrial adenocarcinoma F-prostanoid (FP) receptor expression is elevated, along with its ligand ...
Keightley Margaret C, Sales Kurt J, Jabbour Henry N   +2 more
doaj   +1 more source

Expression of ADAMTS1 during murine development

Mechanisms of Development, 2002
ADAMTS1/METH1 belongs to the ADAMTS (a disintegrin and metalloprotease with thrombospondin repeats) family of proteins that currently comprises 18 members. Targeted inactivation of the ADAMTS1 gene results in morphological defects in the kidney, adrenal gland, and adipose tissue in addition to growth retardation and infertility in females.
Thai, Shelley N.-M., Iruela-Arispe, M.Luisa   +1 more
openaire   +2 more sources

ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

Biomolecules, 2020
Gliomas in general and the more advanced glioblastomas (GBM) in particular are the most usual tumors of the central nervous system with poor prognosis.
Orlando Serrano-Garrido, Carlos Peris-Torres, Silvia Redondo-García, Helena G. Asenjo, María del Carmen Plaza-Calonge, José Luis Fernandez-Luna, Juan Carlos Rodríguez-Manzaneque   +6 more
doaj   +1 more source

The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity [PDF]

, 2023
A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS1) is a protease involved in fertilization, cancer, cardiovascular development, and thoracic aneurysms.
Qi, Yawei, Lee, K, Lee, Karen, Qi, Y, Santamaria, S, Santamaria, Salvatore, Ahnström, Josefin, Josefin Ahnström, Minns, AF, Yamamoto, K, Alexander Frederick Minns, Karen Lee, Yawei Qi, Yamamoto, Kazuhiro, Kazuhiro Yamamoto, Salvatore Santamaria, Ahnström, J, Minns, Alexander Frederick   +17 more
core   +1 more source

ADAMTS-1 in abdominal aortic aneurysm. [PDF]

PLoS ONE, 2017
Extracellular matrix degradation is a hallmark of abdominal aortic aneurysm (AAA). Among proteases that are capable of degrading extracellular matrix are a disintegrin and metalloproteases with thrombospondin motifs (ADAMTS).
Emina Vorkapic, Maggie Folkesson, Kerstin Magnell, Mohammad Bohlooly-Y, Toste Länne, Dick Wågsäter   +5 more
doaj   +1 more source

ADAMTS1 promotes adhesion to extracellular matrix proteins and predicts prognosis in early stage breast cancer patients [PDF]

, 2019
Background/Aims: Despite, several studies demonstrating pro-metastatic effects of the metalloproteinase ADAMTS1 in breast cancer, its role in facilitating the metastatic cascade remains unclear.
Frewin, K., Russell, D.L., Tan, I.A., Ricciardelli, C.   +3 more
core   +1 more source