Results 131 to 140 of about 5,511,471 (226)

A Case of Atypical Hemolytic Uremic Syndrome With a Complement Factor I Mutation Triggered by a Femoral Neck Fracture

Nephrology, Volume 30, Issue 3, March 2025.
ABSTRACT Atypical hemolytic uremic syndrome is a thrombotic microangiopathy caused by the abnormal activation of the alternative complement pathway. Mutations in complement‐related genes and autoantibodies against complement regulators are involved in the pathogenesis of this condition; the frequency of, and prognosis of patients harbouring, each ...
Toshiki Kano, Hiroaki Io, Yu Sasaki, Masahiro Muto, Sayaka Muto, Kei Ogiwara, Arisa Ikeda, Hiroyuki Iwasaki, Yusuke Suzuki   +8 more
wiley   +1 more source

Identification and management of atypical Hemolytic Uremic Syndrome immediately post heart transplantation [PDF]

, 2015
Atypical hemolytic uremic syndrome (aHUS) is a serious hematologic disorder with high mortality if left untreated. A comprehensive literature review revealed only two cases of aHUS post–heart transplantation.
Hadi, M. Azam, Hashmi, Zubair A., Vardas, Panos N.   +2 more
core   +1 more source

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering.

Blood, 2019
Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf ...
Jian Zhu, J. Muia, G. Gupta, L. A. Westfield, K. Vanhoorelbeke, N. Tolia, J. Sadler   +6 more
semanticscholar   +1 more source

Characterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation—A narrative review

American Journal of Hematology, Volume 100, Issue 2, Page 285-295, February 2025.
Abstract The recent report of the first pig kidney transplant in a living human brings hope to thousands of people with end‐stage kidney failure. The scientific community views this early success with caution as kidney xenotransplantation exhibits many challenges and barriers. One of these is coagulation dysregulation.
Ali Zidan, Adham H. El‐Sherbini, Abdelrahman Noureldin, David K. C. Cooper, Maha Othman   +4 more
wiley   +1 more source

Global protein function prediction in protein-protein interaction networks [PDF]

Nature Biotech. 21, 697-700 (2003), 2003
The determination of protein functions is one of the most challenging problems of the post-genomic era. The sequencing of entire genomes and the possibility to access gene's co-expression patterns has moved the attention from the study of single proteins or small complexes to that of the entire proteome. In this context, the search for reliable methods
arxiv  

A Single Synonymous Variant (c.354G>A [p.P118P]) in ADAMTS13 Confers Enhanced Specific Activity

International Journal of Molecular Sciences, 2019
Synonymous variants within coding regions may influence protein expression and function. We have previously reported increased protein expression levels ex vivo (~120% in comparison to wild-type) from a synonymous polymorphism variant, c.354G>A [p.P118P],
R. Hunt, Gaya K. Hettiarachchi, Upendra K. Katneni, Nancy E. Hernandez, David Holcomb, Jacob Kames, Redab Alnifaidy, B. Lin, N. Hamasaki-Katagiri, Aaron Wesley, T. Kafri, Christina Morris, Laura Bouché, M. Panico, T. Schiller, J. Ibla, H. Bar, A. Ismail, H. Morris, A. Komar, C. Kimchi-Sarfaty   +20 more
semanticscholar   +1 more source

Relationships Among Circulating Levels of Hemostasis Inhibitors, Chemokines, Adhesion Molecules, and MRI Characteristics in Multiple Sclerosis

Frontiers in Neurology, 2020
Background: Several studies suggested cross talk among components of hemostasis, inflammation, and immunity pathways in the pathogenesis, neurodegeneration, and occurrence of cerebral microbleeds (CMBs) in multiple sclerosis (MS).Objectives: This study ...
Nicole Ziliotto, Robert Zivadinov, Robert Zivadinov, Dejan Jakimovski, Marcello Baroni, Niels Bergsland, Niels Bergsland, Deepa P. Ramasamy, Bianca Weinstock-Guttman, Murali Ramanathan, Giovanna Marchetti, Francesco Bernardi   +11 more
doaj   +1 more source

ADAMTS13: A New Link Between Thrombosis and Inflammation [PDF]

, 2011
von Willebrand factor (VWF) levels are elevated and a disintegrin-like and metalloprotease with thrombospondin type I repeats–13 (ADAMTS13) activity is decreased in both acute and chronic inflammation.
Brill, Alexander, Chauhan, Anil K., Kisucka, Janka, Scheiflinger, Friedrich, Wagner, Denisa D., Walsh, Meghan T.   +5 more
core   +1 more source

Thrombotic Thrombocytopenic Purpura in Oman: Disease Burden and Outcomes

Oman Medical Journal
Objectives: Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening autoimmune disorder; limited information about this disease is available from the Middle East.
Samata Al Dowaiki, Khalid Al Hashmi, Sulayma Al-Lamki, Muhana Al Muselhi, Murtadha Al-Khabori   +4 more
doaj   +1 more source

Multi-lectin Affinity Chromatography and Quantitative Proteomic Analysis Reveal Differential Glycoform Levels between Prostate Cancer and Benign Prostatic Hyperplasia Sera. [PDF]

, 2018
Currently prostate-specific antigen is used for prostate cancer (PCa) screening, however it lacks the necessary specificity for differentiating PCa from other diseases of the prostate such as benign prostatic hyperplasia (BPH), presenting a clinical need
Adusumilli, Ravali, Brooks, James D, Kullolli, Majlinda, Mallick, Parag, Pitteri, Sharon J, Tanimoto, Cheylene, Totten, Sarah M   +6 more
core   +2 more sources