Results 121 to 130 of about 3,354,179 (197)

[Management of congenital thrombotic thrombocytopenic purpura in the era of recombinant ADAMTS13 protein: Recommendations from the Reference Center for Thrombotic Microangiopathies (CNR-MAT)].

La Revue de medecine interne
Thrombotic Thrombocytopenic Purpura (TTP) is a rare disease characterized by a severe deficiency of ADAMTS13, the specific protease that cleaves von Willebrand factor. The congenital form of TTP (cTTP) results from pathogenic variants of the ADAMTS13 gene.
Joly, Bérangère S., Veyradier, Agnès, Coppo, Paul, Joseph, Adrien, Dossier, Claire, Kwon, Theresa, Gouge-Biebuyck, Nathalie, Boyer, Olivia, Tsatsaris, Vassilis   +8 more
openaire   +2 more sources

Can Plasma ADAMTS13 Differentiate Patients With Pulmonary Arterial Hypertension From Other Forms of Pulmonary Hypertension and Dyspnea Control PatientsTake-Home Points

CHEST Pulmonary
Background: Multimarker panels of blood-borne biomarkers could aid in shortening the diagnostic delay of pulmonary arterial hypertension (PAH). Research Question: Can any of the 61 proteins included in the study, related to pathways known to be involved ...
Kriss Kania, MD, Abdulla Ahmed, MD, Salaheldin Ahmed, MD, Adam Engel Sällberg, MD, Karin Tran-Lundmark, MD, PhD, Jørn Carlsen, MD, PhD, Göran Rådegran, MD, DMSc, MSc Eng Phys   +6 more
doaj   +1 more source

PROTEOLYTIC PROCESSING OF VON WILLEBRAND FACTOR BY ADAMTS13 AND LEUKOCYTE PROTEASES-rev1-MJHID-2013

Mediterranean Journal of Hematology and Infectious Diseases, 2014
ADAMTS13 is a 190 kDa zinc protease encoded by a gene located on chromosome 9q34.   This protease specifically hydrolyzes von Willebrand factor (VWF) multimers, thus causing VWF size reduction.
Raimondo De Cristofaro
doaj  

ADAMTS13 in arterial thrombosis [PDF]

, 2010
The aim of this thesis was to study the role of ADAMTS13 in arterial thrombosis, a disease that comprises both environmental and genetic factors. We determined ADAMTS13 in ischemic stroke patients and controls.
Bongers, T.N. (Tamara)
core  

Specific activity of ADAMTS13 variants and limited proteolysis with trypsin.

, 2012
A. Specific activity of twelve ADAMTS13 variants vs. WT as determined using FRETS-VWF73 substrate: Samples containing equal amounts of total extracellular protein were incubated with 5 µM of FRETS-VWF73 substrate and fluorescence readings were taken at 5
Anton A. Komar (154543), Jordan Newell (154512), Zachary A. Hing (154493), Nathan C. Edwards (154490), Teresa M. Przytycka (17022), William Plum (154511), Noam Shomron (86157), Avital Perry (154497), Chava Kimchi-Sarfaty (154547), Idit Kosti (114827), Geetha S. (154517), Adam Blaisdell (154502), Yael Mandel-Gutfreund (13342), Vahan Grigoryan (154530), David B. Kopelman (154506), Aaron Shapiro (154520), Zuben E. Sauna (154537), Robert Fathke (154509), Chinyere Okunji (154525), Raheleh Salari (138728), Courtni E. Allen (154514)   +20 more
core   +1 more source

SNPs in ADAMTS13

, 2011
The multidomain metalloprotease ADAMTS13 limits thrombus formation via the cleavage of large multimeric forms of von Willebrand factor. Deficiency of functional ADAMTS13 is associated with a number of disease pathologies including thrombotic ...
Chava Kimchi-Sarfaty, Sandra Chang Tseng
core   +1 more source

Púrpura trombocitopênica trombótica: o papel do fator von Willebrand e da ADAMTS13 Thrombotic thrombocytopenic purpura: the role of von Willebrand factor and ADAMTS13

Revista Brasileira de Hematologia e Hemoterapia, 2010
A púrpura trombocitopênica trombótica (PTT) instala-se de modo abrupto e é caracterizada pela oclusão difusa de arteríolas e capilares da microcirculação, levando à isquemia de tecidos.
Leandro C. Tonaco, Danyelle R. A. Rios, Lauro M. Vieira, Maria das Graças Carvalho, Luci M. S. Dusse   +4 more
doaj  

Recognizing thrombotic thrombocytopenic purpura beyond the pentad. [PDF]

Oxf Med Case Reports
Pupiec OM, Levin JR, Cooley CN, Paratore D.   +3 more
europepmc   +1 more source

Endotheliopathy in CAR T-Cell Therapy: Mechanistic Insights into the VWF/ADAMTS13 Axis and the Angiopoietin-Tie2 Pathway. [PDF]

TH Open
de Bruijn S, Vangenechten I, Anguille S, Gadisseur A.   +3 more
europepmc   +1 more source

Acquired immune-mediated thrombotic thrombocytopenic purpura with severe cholestatic liver injury and reversible acute kidney injury after ivonescimab-containing chemoimmunotherapy: a case report and literature review. [PDF]

Front Immunol
Chen Q, Song X, Zhang M, Niu H, Guo W.
europepmc   +1 more source