Results 101 to 110 of about 3,354,179 (197)

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]

, 2018
Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias, Sub Cellular Protein Chemistry, Kityk, R., Rüdiger, S.G.D., Morán Luengo, T., Cellular Protein Chemistry   +5 more
core   +2 more sources

A Comparative Analysis of the Roles of von Willebrand Factor and ADAMTS13 in Hepatocellular Carcinoma: A Bioinformatics and Microarray-Based Study

Current Issues in Molecular Biology
Genetic and epigenetic alterations of various biomolecules at the molecular level can contribute to the pathogenesis of hepatocellular carcinoma (HCC) and negative impact prognosis.
Durmuş Ayan, Şerife Buket Bozkurt Polat, Ergül Bayram, Esma Özmen, Fatma Esin Aydın, Serpil Ersan   +5 more
doaj   +1 more source

Expressed protein ligation for a large dimeric protein [PDF]

, 2011
Expressed protein ligation (EPL) is a protein engineering tool for post-translational ligation of protein or peptide fragments. This technique allows modification of specific parts of proteins, opening possibilities for incorporating probes for ...
NMR Spectroscopy, Karagöz, G.E., Sub Cellular Protein Chemistry, O. Hsieh, Sub NMR Spectroscopy, T. Sinnige, Rüdiger, S.G.D., Hsieh, O., Sinnige, T, G. E. Karagoz, S. G. D. Rudiger, Cellular Protein Chemistry   +11 more
core   +1 more source

Congenital thrombotic thrombocytopenic purpura: a rare cause of severe neonatal jaundice and hypoxic respiratory failure – a case report

Case Reports in Perinatal Medicine
This report describes the case of an infant with congenital thrombotic thrombocytopenic purpura.
Al Mandhari Hilal, Albulushi Fatma, Al-Mashaikhi Nawal   +2 more
doaj   +1 more source

Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS

Blood Advances
: Allosteric regulation of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type-1 motif, member 13) activity involves an interaction between its spacer (S) and 2 complement C1r/C1s, Uegf and BMP1 (CUB; CUB1-2) domains to keep the enzyme
Quintijn Bonnez, Emily R. Legan, Inge Pareyn, Febe Boudry, Jennifer Anckaert, Claudia Tersteeg, Simon F. De Meyer, Renhao Li, Karen Vanhoorelbeke   +8 more
doaj   +1 more source

Nonsense-mediated mRNA decay in the ADAMTS13 gene caused by a 29-nucleotide deletion

Haematologica, 2008
Background In mammalian cells a regulatory mechanism, known as nonsense-mediated mRNA decay, degrades mRNA harboring premature termination codons. This mechanism is intron-dependent and functions as a quality control mechanism to eliminate abnormal ...
Isabella Garagiola, Carla Valsecchi, Silvia Lavoretano, Hale Oren, Martina Bohm, Flora Peyvandi   +5 more
doaj   +1 more source

ADAMTS13 deficiency leads to early and progressive BBB breakdown in APPPS1 mice.

, 2019
(A) In vivo multiphoton microscopy images of intravenously injected FITC-dextran (MW = 40,000 Da; green) leakage in cortical vessels in 2-, 6-, and 12-month-old WT, Adamts13−/−, APPPS1, and APPPS1–Adamts13−/− mice. Scale bar, 100 μm.
Ranran Wang (476935), Mei-Juan Shi (6824087), Lixiang Wei (6559682), Yuanyuan Ma (280707), Yiqian Shi (6415292), Xing Yang (262520), Jin Zhang (53297), Haiyu Luo (6559679), Lijing Kang (6559685), Yun Wang (32846), Yongliang Cao (6559688), Bing-Qiao Zhao (6559691), Xiaofei Bai (695040), Zhongfeng Wang (313048), Haochen Xu (6824081), Lu Lu (392), Yuanbo Zhu (6824084), Shuo Cheng (551385), Kai Zhong (423362), Wenying Fan (6162569), Haiyang Tong (6499709)   +20 more
core   +1 more source

Characterizing Protease-Resistant ADAMTS13 Mutants [PDF]

, 2023
ADAMTS13 is a metalloprotease that regulates the length, and thus, the platelet-capturing capacity of von Willebrand factor. The regulation of ADAMTS13 activity remains poorly understood. Numerous circulating proteases cleave ADAMTS13 in vitro, impairing
DeYoung, Veronica A
core  

Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein [PDF]

, 2012
A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton
Sychrovský, V., Sub Cellular Protein Chemistry, Sebera, J., Tanaka, Y., Trantirek, L., Cellular Protein Chemistry   +5 more
core   +1 more source

Successful Treatment of Refractory Immune Thrombotic Thrombocytopenic Purpura with Daratumumab

Клиническая онкогематология
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare life-threatening disease manifested by thrombocytopenia, microangiopathic hemolytic anemia, and impaired functions of organs and systems due to the thrombosis of small arteries.
E. E. Klebanova, Gennadii Martinovich Galstyan, S. Yu. Mamleeva, D. K. Bessmertnyy, Z. T. Fidarova, E. N. Parovichnikova   +5 more
doaj   +1 more source