Results 81 to 90 of about 8,844 (195)

Effect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock

Critical Care, 2020
Background A dysbalanced coagulation system is part of the pathological host response to infection in sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant activity ultimately lead to microvascular stasis and consequent organ ...
Klaus Stahl, Julius J. Schmidt, Benjamin Seeliger, Bernhard M. W. Schmidt, Tobias Welte, Hermann Haller, Marius M. Hoeper, Ulrich Budde, Christian Bode, Sascha David   +9 more
doaj   +1 more source

A case of refractory thrombotic thrombocytopenic purpura treated with plasmapheresis and rituximab [PDF]

, 2016
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder with no prevalence or incidence studies in sub-Saharan Africa. Acquired TTP has several causes, all of which lead to decreased activity of von Willebrand factor cleaving ...
Kirui, Nicholas, Sokwala, Ahmed
core   +4 more sources

Dried plasma retains hemostatic function and thermal stability during Arctic military operations

Transfusion, Volume 66, Issue S1, Page S159-S171, May 2026.
Abstract Background Dried plasma offers a practical alternative for remote damage control resuscitation, providing hemostatic support and volume replacement. The Arctic presents challenges that necessitate the need for blood‐based resuscitation to extend the “golden hour.” To address this, we evaluated the hemostatic and thermal stability of dried ...
Kanwal Singh, Aron A. Shoara, Henry T. Peng, Viktor Prifti, Katy Moes, Cerys McGuinness, Tristan Bonnici, Maria Shiu, Sushmaa Chandralekha Selvakumar, Peter Andrisani, Pierre‐Marc Dion, Damien Miller, Sebastian Vuong, Colin A. Kretz, Philip J. Wallace, Shawn G. Rhind, Wendy Sullivan‐Kwantes, Andrew N. Beckett   +17 more
wiley   +1 more source

Bethesda Assay for Detecting Inhibitory Anti-ADAMTS13 Antibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura

TH Open, 2018
A diagnosis of thrombotic thrombocytopenic purpura (TTP) is confirmed by a severe deficiency (
Chiara Vendramin, Mari Thomas, John-Paul Westwood, Marie Scully   +3 more
doaj   +1 more source

Structural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experiments. [PDF]

PLoS ONE, 2012
The hemostatic function of von Willebrand factor is downregulated by the metalloprotease ADAMTS13, which cleaves at a unique site normally buried in the A2 domain.
Gianluca Interlandi, Minhua Ling, An Yue Tu, Dominic W Chung, Wendy E Thomas   +4 more
doaj   +1 more source

Plasma von Willebrand factor levels predict in-hospital survival in patients with acute-on-chronic liver failure [PDF]

, 2016
BACKGROUND AND AIMS: Circulating levels of von Willebrand factor (vWF) predict mortality in patients with cirrhosis. We hypothesized that systemic inflammation in acute-on-chronic liver failure (ACLF) will stimulate endothelium, increase vWF levels, and ...
Amirtharaj, GJ, Balasubramanian, KA, Eapen, CE, Elias, E, Goel, A, Mackie, I, Prasanna, KS, Ramachandran, A, Sajith, KG, Zachariah, U   +9 more
core   +1 more source

Concomitant Immune‐Mediated Thrombotic Thrombocytopenic Purpura and Evans Syndrome With Multiple Cerebral Infarctions in an Elderly Patient

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT We report a rare case of concomitant immune thrombotic thrombocytopenic purpura (iTTP) and Evans syndrome, complicated by multiple cerebral infarctions. The patient presented with severe thrombocytopenia and hemolytic anemia, as well as a positive direct Coombs test. The initial diagnosis was Evans syndrome.
Shinichi Ogawa, Yangsu Kim, Takayoshi Ito   +2 more
wiley   +1 more source

Anti-ADAMTS13 Autoantibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura

Antibodies
Autoantibodies to ADAMTS13 are at the center of pathology of the immune-mediated thrombotic thrombocytopenic purpura. These autoantibodies can be either inhibitory (enzymatic function) or non-inhibitory, resulting in protein depletion.
Michael R. Snyder, Robert W. Maitta
doaj   +1 more source

The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study

BMC Medicine, 2023
Background Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6–10% of all reproductive-aged women.
Yan Li, Hongyan Liu, Shuting Ye, Bumei Zhang, Xiaopei Li, Jiapei Yuan, Yongrui Du, Jianmei Wang, Yang Yang   +8 more
doaj   +1 more source

Physical Fitness Is Negatively Associated With DNA Methylation‐Based Risk of Aging‐Related Diseases

Aging Cell, Volume 25, Issue 4, April 2026.
We found 33 significant associations between DNA methylation–based protein level estimates (EpiScores) and fitness traits in older adults. Then we found 51 associations between fitness traits and chronic age‐related diseases, enabling a workflow for evaluating patient‐level disease risk by using DNA methylation and fitness measurements.
Samiha Nasser, Johanna Keringer, Yaodong Gu, Istvan Boldogh, Xueqing Ba, Mitsuru Higuchi, Csaba Kerepesi, Zsolt Radak   +7 more
wiley   +1 more source