Results 81 to 90 of about 3,354,179 (197)
International Journal of Cancer, Volume 159, Issue 5, Page 1337-1344, 1 September 2026.Although immune checkpoint inhibitors (ICI) have transformed metastatic melanoma treatment, thromboembolic events (TEEs) remain a serious complication. Moreover, existing risk assessment models were developed prior to ICI use and lack clinical validation.
Tim Zell +12 more
wiley +1 more source
Plasma level and clinical significance of ADAMTS13 in patients with primary membrous nephropathy
Linchuang shenzangbing zazhi, 2022 ObjectivePatients with primary membrous nephropathy （PMN） have an elevated risk of venous thromboembolism （VTE）. The aim of this study was to detect plasma level of ADAMTS13 in PMN patients complicated and uncomplicated by VTE and examine their clinical ...
Zhu Guo-qiang +3 more
doaj
Detection of Plasma Protease Activity Using Microsphere-Cytometry Assays with E. coli Derived Substrates: VWF Proteolysis by ADAMTS13. [PDF]
PLoS ONE, 2015 Protease levels in human blood are often prognostic indicators of inflammatory, thrombotic or oncogenic disorders. The measurement of such enzyme activities in substrate-based assays is complicated due to the low prevalence of these enzymes and steric ...
Shobhit Gogia +2 more
doaj +1 more source
Protein Science, Volume 35, Issue 9, September 2026.Abstract Snake envenomation remains a critical global public health challenge. In Brazil, the genus Bothrops is responsible for most accidents, typically resulting in coagulopathy, hemorrhage, and renal failure. Despite its clinical prevalence, the molecular mechanisms driving plasma protein disturbances remain poorly understood.
Bianca C. S. C. de Barros +6 more
wiley +1 more source
Conformational activation of ADAMTS13 [PDF]
, 2014 A disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13) is a metalloprotease that regulates von Willebrand factor (VWF) function. ADAMTS13-mediated proteolysis is determined by conformational changes in VWF, but also may depend on its ...
South, Kieron; id_orcid +23 more
core +1 more source
Anti-ADAMTS13 Autoantibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura
AntibodiesAutoantibodies to ADAMTS13 are at the center of pathology of the immune-mediated thrombotic thrombocytopenic purpura. These autoantibodies can be either inhibitory (enzymatic function) or non-inhibitory, resulting in protein depletion.
Michael R. Snyder, Robert W. Maitta
doaj +1 more source
Critical Care, 2020 Background A dysbalanced coagulation system is part of the pathological host response to infection in sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant activity ultimately lead to microvascular stasis and consequent organ ...
Klaus Stahl +9 more
doaj +1 more source
Structural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experiments. [PDF]
PLoS ONE, 2012 The hemostatic function of von Willebrand factor is downregulated by the metalloprotease ADAMTS13, which cleaves at a unique site normally buried in the A2 domain.
Gianluca Interlandi +4 more
doaj +1 more source
Role of defensins in immunothrombosis
Rheumatology &Autoimmunity, Volume 6, Issue 3, Page 138-148, September 2026.Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang +7 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang +12 more
wiley +1 more source