Results 61 to 70 of about 3,354,179 (197)

Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C

Molecular Medicine, 2015
In sepsis, the severity-dependent decrease of von Willebrand factor (VWF)-inactivating protease, a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13), results in platelet aggregation and consumption, leading to sepsis-associated thrombotic microangiopathy (TMA) and organ failure.
Michael L, Ekaney, Clemens L, Bockmeyer, Maik, Sossdorf, Philipp A, Reuken, Florian, Conradi, Tobias, Schuerholz, Markus F, Blaess, Scott L, Friedman, Wolfgang, Lösche, Michael, Bauer, Ralf A, Claus   +10 more
openaire   +2 more sources

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

ADAMTS13 and Myocardial Infarction: A Literature Review [PDF]

, 2022
Background: Myocardial infarction (MI) is the most common cause of death worldwide. Important modifiable risk factors have been unraveled and preventive measures established, but the disease burden remains substantial.
Edvardsen, Magnus Sandvik
core  

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

ADAMTS13 activity in sickle cell disease

, 2006
Sickle red blood cell (SRBC)-endothelial adhesion plays a central role in sickle cell disease (SCD)-related vaso-occlusion. As unusually large von Willebrand factor (ULVWF) multimers mediate SRBC-endothelial adhesion, we investigated the activity of ...
Krieg, S, Mac Gillavry, MR, Duits, AJ, Hovinga, JA, Akin, S, CURAMA, Study Group, Lämmle, B, Schnog, JJ, Brandjes, DP, Muskiet, FD   +9 more
core   +1 more source

Recombinant expression of the thrombolytic agent ADAMTS13

, 2022
Thromboembolien stellen eine der häufigsten Todesursachen in der westlichen Welt dar. Die Bildung eines Thrombus basiert auf einem natürlichen Mechanismus ein verletztesBlutgefäß zu reparieren. Die pathologische Bildung von Thromben, die groß genug sind,
Eckhart, Alexandra Stefanie
core   +1 more source

Shedding Light on the Possible Link between ADAMTS13 and Vaccine—Induced Thrombotic Thrombocytopenia

Cells, 2021
Several recent reports have highlighted the onset of vaccine-induced thrombotic thrombocytopaenia (VITT) in some recipients (approximately 1 case out of 100k exposures) of the ChAdOx1 nCoV-19 vaccine (AstraZeneca).
Anna Szóstek-Mioduchowska, Paweł Kordowitzki   +1 more
doaj   +1 more source

Plasma ADAMTS13 activity in healthy dogs and dogs with chronic enteropathy

Journal of Small Animal Practice, EarlyView.
Objectives A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 is a von Willebrand factor cleaving enzyme that is associated with prothrombotic/hypercoagulable states in humans. In people, A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity is reduced with inflammatory bowel disease ...
S. I. Barth, S. M. DeMonaco, B. J. Conner, P. B. S. Serpa, A. R. Wilkinson   +4 more
wiley   +1 more source

The activity is secreted and intracellular ADAMTS13.

, 2013
Activity of secreted (•) and intracellular ADAMTS13 (▪). Activity of intracellular ADAMTS13 was measured using the FRETS-VWF73 assay described in Fig. 4.
Tanvi Gupta (371279), Adam Blaisdell (154502), Geetha S (371281), Elizabeth Plum (371280), Vahan Grigoryan (154530), Zuben E. Sauna (154537), Chinyere Okunji (154525), Robert Fathke (154509), Kenji Soejima (371282), Chava Kimchi-Sarfaty (154547), Ryan C. Hunt (371278), Courtni E. Allen (154514)   +11 more
core   +1 more source

Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpura [PDF]

, 2011
Severe ADAMTS13 deficiency is a critical component of the pathogenesis of idiopathic thrombotic thrombocytopenic purpura but is found only in about 60% of patients clinically diagnosed with this ...
J.-F. Dong, J. A. Kremer Hovinga, Kremer Hovinga, Johanna A, Luken, Brenda M., J. Voorberg, Froehlich-Zahnd, Rahel, R. Froehlich-Zahnd, George, James N., Kremer Hovinga, Johanna A., D. R. Terrell, George, James N, Vesely, Sara K, K. Aboulfatova, Aboulfatova, Khatira, Lämmle, Bernhard, J. N. George, Vesely, Sara K., Terrell, Deirdra R, S. K. Vesely, Terrell, Deirdra R., B. M. Luken, Luken, Brenda M, Budde, Ulrich, Sulzer, Irmela, Dong, Jing-Fei, Voorberg, Jan, U. Budde, B. Lammle, I. Sulzer   +28 more
core   +1 more source