Results 51 to 60 of about 5,721 (151)

Detection of Plasma Protease Activity Using Microsphere-Cytometry Assays with E. coli Derived Substrates: VWF Proteolysis by ADAMTS13. [PDF]

PLoS ONE, 2015
Protease levels in human blood are often prognostic indicators of inflammatory, thrombotic or oncogenic disorders. The measurement of such enzyme activities in substrate-based assays is complicated due to the low prevalence of these enzymes and steric ...
Shobhit Gogia, Chi Y Lo, Sriram Neelamegham   +2 more
doaj   +1 more source

Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF‐κB and STAT3 pathways in osteosarcoma

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract Osteosarcoma (OS) is an aggressive bone malignancy characterized by genomic instability and extensive extracellular matrix (ECM) remodeling. Members of the ADAMTS family are matrix‐associated proteases implicated in tumorigenesis; however, their roles in OS remain poorly defined. This study provides a comprehensive genomic, transcriptomic, and
Ehed Muhammed Aymaz, Meltem Alper, Feyza Nur Sav, Tuğşen Aydemir, Feray Köçkar   +4 more
wiley   +1 more source

Plasma level and clinical significance of ADAMTS13 in patients with primary membrous nephropathy

Linchuang shenzangbing zazhi, 2022
ObjectivePatients with primary membrous nephropathy （PMN） have an elevated risk of venous thromboembolism （VTE）. The aim of this study was to detect plasma level of ADAMTS13 in PMN patients complicated and uncomplicated by VTE and examine their clinical ...
Zhu Guo-qiang, Yang Shu-fen, Zhang Xue-qing, Lu Chen   +3 more
doaj  

The ADAMTS131239–1253 peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope

Haematologica, 2017
Acquired thrombotic thrombocytopenic purpura is a rare and severe disease characterized by auto-antibodies directed against “A Disintegrin And Metalloproteinase with Thrombospondin type 1 repeats, 13th member" (ADAMTS13), a plasma protein involved in ...
Laurent Gilardin, Sandrine Delignat, Ivan Peyron, Mathieu Ing, Yu-Chun Lone, Bagirath Gangadharan, Baptiste Michard, Yousra Kherabi, Meenu Sharma, Anastas Pashov, Jean-Baptiste Latouche, Mohamad Hamieh, Olivier Toutirais, Pascale Loiseau, Lionel Galicier, Agnès Veyradier, Srini Kaveri, Bernard Maillère, Paul Coppo, Sébastien Lacroix-Desmazes   +19 more
doaj   +1 more source

Effect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock

Critical Care, 2020
Background A dysbalanced coagulation system is part of the pathological host response to infection in sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant activity ultimately lead to microvascular stasis and consequent organ ...
Klaus Stahl, Julius J. Schmidt, Benjamin Seeliger, Bernhard M. W. Schmidt, Tobias Welte, Hermann Haller, Marius M. Hoeper, Ulrich Budde, Christian Bode, Sascha David   +9 more
doaj   +1 more source

Structural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experiments. [PDF]

PLoS ONE, 2012
The hemostatic function of von Willebrand factor is downregulated by the metalloprotease ADAMTS13, which cleaves at a unique site normally buried in the A2 domain.
Gianluca Interlandi, Minhua Ling, An Yue Tu, Dominic W Chung, Wendy E Thomas   +4 more
doaj   +1 more source

Bethesda Assay for Detecting Inhibitory Anti-ADAMTS13 Antibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura

TH Open, 2018
A diagnosis of thrombotic thrombocytopenic purpura (TTP) is confirmed by a severe deficiency (
Chiara Vendramin, Mari Thomas, John-Paul Westwood, Marie Scully   +3 more
doaj   +1 more source

Post‐Transfusion Purpura: A Clinical Case With Alveolar Haemorrhage

Respirology Case Reports, Volume 14, Issue 6, June 2026.
We report a case of post‐transfusion thrombocytopenic purpura and alveolar haemorrhage in a woman after knee replacement surgery, occurring 7 days after transfusion of 20 mL of blood. This case was successfully treated with therapeutic plasma exchange and intravenous immunoglobulin.
Yordanka Yamakova, Aleksandar Pisanchev, Aleksandar Farfarov, Rosen Petkov   +3 more
wiley   +1 more source

Anti-ADAMTS13 Autoantibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura

Antibodies
Autoantibodies to ADAMTS13 are at the center of pathology of the immune-mediated thrombotic thrombocytopenic purpura. These autoantibodies can be either inhibitory (enzymatic function) or non-inhibitory, resulting in protein depletion.
Michael R. Snyder, Robert W. Maitta
doaj   +1 more source

The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study

BMC Medicine, 2023
Background Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6–10% of all reproductive-aged women.
Yan Li, Hongyan Liu, Shuting Ye, Bumei Zhang, Xiaopei Li, Jiapei Yuan, Yongrui Du, Jianmei Wang, Yang Yang   +8 more
doaj   +1 more source