Extracellular Vesicle Surface Protein Profiling in Metabolic Dysfunction-associated Steatotic Liver Disease in Obesity. [PDF]
J Extracell BiolABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is highly prevalent in obesity, but scalable tools for biological risk stratification remain limited. In this cross‐sectional, single‐centre discovery study (MULTISITE), we profiled circulating extracellular vesicle (cEV) surface proteins by EV Array in platelet‐poor plasma from ...
Garcia NA +8 more
europepmc +2 more sources
Chinese Journal of Physiology, 2023 Deep vein thrombosis (DVT) is a common complication in hematologic malignancies and immunologic disorders. Endothelial cell injury and dysfunction comprise the critical contributor for the development of DVT.
Guangfeng Zheng +7 more
doaj +1 more source
Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. [PDF]
, 2009 The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome.
Hársfalvi, Jolán +9 more
core +1 more source
Recombinant ADAMTS13 for Hereditary Thrombotic Thrombocytopenic Purpura. [PDF]
, 2022 A 27-year-old patient with a history of severe obstetrical complications and arterial thrombosis received a diagnosis of hereditary thrombotic thrombocytopenic purpura (TTP) due to severe ADAMTS13 deficiency when she presented with an acute episode in ...
Ganter, Michael T +9 more
core +1 more source
Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure. [PDF]
, 2009 Decreased activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease, was recently reported in cardiovascular diseases and in hepatic failure.
Borgulya, Gábor +10 more
core +1 more source
Von Willebrand factor, ADAMTS13 and mortality in dialysis patients
BMC Nephrology, 2021 Background Von Willebrand Factor (VWF) multimers are cleaved into smaller and less coagulant forms by the metalloprotease ADAMTS13. The aim of this study was to investigate the association between VWF and ADAMTS13 and mortality in dialysis patients ...
Gurbey Ocak +8 more
doaj +1 more source
S109 Adamts13 protein levels are decreased in chronic thromboembolic pulmonary hypertension and implicated in its pathobiology [PDF]
Advances in understanding chronic thrombo-embolic disease and pulmonary hypertension, 2017 Introduction Chronic thromboembolic pulmonary hypertension (CTEPH) Results from failure of thrombus resolution following acute pulmonary embolism. Abnormalities in haemostasis are implicated in the pathobiology, including elevated levels of von Willebrand factor (VWF), which is normally regulated by ADAMTS13.
M Newnham +14 more
openaire +1 more source
Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
core +1 more source
Mechanism of ADAMTS13 regulation [PDF]
, 2022 Studies demonstrated ADAMTS13 possesses unique properties with a mystifying regulatory mechanism. ADAMTS13’s role is in its proteolytic function to its VWF.
Madarati, Hasam
core +1 more source
Scientific Reports, 2022 Ubiquitous microthromboses in the pulmonary vasculature play a crucial role in the pathogenesis of COVID-19 associated acute respiratory distress syndrome (ARDS). Excess of Willebrand factor (vWf) with intravascular multimer formation was identified as a
Felix S. Seibert +13 more
doaj +1 more source