Results 21 to 30 of about 3,354,179 (197)

Rat models of thrombotic thrombocytopenic purpura reveal crucial role of placental ADAMTS13 in perinatal survival [PDF]

Blood Advances
: Thrombotic thrombocytopenic purpura (TTP), a life-threatening thrombotic microangiopathy, is caused by severe deficiency of plasma ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, 13) activity.
Quan Zhang, Liang Zheng, Zhirong Chai, Zhijian Wu, Esteban M. Dominguez, Michael J. Soares, X. Long Zheng   +6 more
doaj   +2 more sources

Plasma von Willebrand Factor and ADAMTS13 Interact With APOE‐ε4 in Predicting Longitudinal Brain Atrophy and Cognitive Decline Over a 9‐Year Follow‐Up [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Von Willebrand factor (VWF) and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13) are linked to dementia risk, and limited evidence suggests apolipoprotein E (APOE)‐ε4 alters VWF release.
Hailey A. Adegboye, Yunyi Sun, Panpan Zhang, Dandan Liu, Omair A. Khan, Kahraman Tanriverdi, Antonina Risitano, Julia Libby, Khiry L. Patterson, Albert B. Arul, Nekesa C. Oliver, Marsalas D. Whitaker, Vaibhav A. Janve, Logan C. Dumitrescu, Kimberly R. Pechman, Niranjana Shashikumar, Corey J. Bolton, L. Taylor Davis, Bennett A. Landman, Jane E. Freedman, Renã A. S. Robinson, Timothy J. Hohman, Angela L. Jefferson   +22 more
doaj   +2 more sources

Factor XI/ADAMTS13 complexes are quantitatively insignificant in human plasma [PDF]

Haematologica, 2007
Reportedly, complexes between factor XI and ADAMTS13 are detected with a commercial ADAMTS13/FXI ELISA kit in plasma and are decreased in thrombotic thrombocytopenic purpura (TTP).
Patricia J. Anderson, David Gailani, Hendrik B. Feys, Weiqiang Gao, Elaine M. Majerus, Karen Vanhoorelbeke, J. Evan Sadler   +6 more
doaj   +2 more sources

TTP-Like Syndrome and Subsequent Non-Aneurysmal Subarachnoid Hemorrhage in HbSC Disease: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Sickle cell disease (SCD) with hemoglobin‐ (Hb‐) SC genotype is often considered a milder SCD variant, yet life‐threatening complications can occur. A 26‐year‐old man with HbSC disease presented with an infection triggered vaso‐occlusive crisis (VOC), acute chest syndrome (ACS), severe thrombocytopenia, Coombs‐negative hemolysis with ...
Vieten B, Vorwerk J, Morf J, Dauth A, Sondermann S, Schramm P, Graf T, von Bubnoff N, Oelschläger L, Khandanpour C.   +9 more
europepmc   +2 more sources

Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients.

PLoS ONE, 2021
Sepsis is a life-threatening disease characterized by excessive host response to infection that can lead to activation of the coagulation system. Von Willebrand Factor (VWF) and ADAMTS13 are important regulators of hemostasis and their dysregulation ...
Kanwal Singh, Andrew C Kwong, Hasam Madarati, Sharumathy Kunasekaran, Taylor Sparring, Alison E Fox-Robichaud, Patricia C Liaw, Colin A Kretz   +7 more
doaj   +1 more source

Characterization of conformation-sensitive antibodies to ADAMTS13, the von Willebrand cleavage protease. [PDF]

PLoS ONE, 2009
BACKGROUND:The zinc metalloprotease ADAMTS13 is a multidomain protein that cleaves von Willebrand Factor (VWF) and is implicated in Thrombotic Thrombocytopenic Purpura (TTP) pathogenesis.
Zuben E Sauna, Chinyere Okunji, Ryan C Hunt, Tanvi Gupta, Courtni E Allen, Elizabeth Plum, Adam Blaisdell, Vahan Grigoryan, S Geetha, Robert Fathke, Kenji Soejima, Chava Kimchi-Sarfaty   +11 more
doaj   +1 more source

ADAMTS13 levels in a plasma-derived FVIII concentrate: A potential therapeutic option for patients with congenital thrombotic thrombocytopenic purpura

Thrombosis Update, 2022
Introduction: Treatment of congenital thrombotic thrombocytopenic purpura (cTTP), a disease characterized by the congenital deficiency of ADAMTS13, remains a challenge as there are no specific treatments available yet, other than therapy based on the use
Filippo Mori, Ilaria Nardini, Silvia Nannizzi, Roberto Crea, Prasad Mathew, Nicole Ziliotto, Alessandro Gringeri   +6 more
doaj   +1 more source

Characterization of coding synonymous and non-synonymous variants in ADAMTS13 using ex vivo and in silico approaches. [PDF]

PLoS ONE, 2012
Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on the properties of the synthesized protein(s).
Nathan C Edwards, Zachary A Hing, Avital Perry, Adam Blaisdell, David B Kopelman, Robert Fathke, William Plum, Jordan Newell, Courtni E Allen, Geetha S, Aaron Shapiro, Chinyere Okunji, Idit Kosti, Noam Shomron, Vahan Grigoryan, Teresa M Przytycka, Zuben E Sauna, Raheleh Salari, Yael Mandel-Gutfreund, Anton A Komar, Chava Kimchi-Sarfaty   +20 more
doaj   +1 more source

Localization of blood proteins thrombospondin1 and ADAMTS13 to cerebral corpora amylacea [PDF]

Neuropathology, 2009
Corpora amylacea (CA) have long been described in aging brains and in patients with neurodegenerative conditions, but their origins have been debated. It has been proposed that CA represent collections of nervous system breakdown products that accumulate within astrocytic cytoplasm.
Meng, He, Zhang, Xiaojie, Blaivas, Mila, Wang, Michael M.   +3 more
openaire   +3 more sources

Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance

Blood Advances, 2022
The effects of synonymous single nucleotide variants (sSNVs) are often neglected since they do not alter protein primary structure. Nevertheless, there is growing evidence that synonymous variations may impact mRNA expression, protein conformation and activity which may lead to protein deficiency and disease manifestations.
Katarzyna Izabela Jankowska, Douglas Meyer, David Dillon Fisher Holcomb, Jacob Kames, Nobuko Hamasaki-Katagiri, Upendra K. Katneni, Ryan C. Hunt, Juan C. Ibla, Chava Kimchi-Sarfaty   +8 more
openaire   +2 more sources