Results 71 to 80 of about 3,354,179 (197)

New Insights Into Pathogenesis, Diagnostics, and Therapeutic Options for Canine Angiostrongylosis

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To provide a comprehensive overview of Angiostrongylus vasorum infection in dogs, with a particular emphasis on recent developments in the understanding of disease pathophysiology and an update on developments in diagnostic and therapeutic options.
Iris Elgueta, Daniel Lewis, Eric R. Morgan, Jenny Helm   +3 more
wiley   +1 more source

ADAMTS13 in Bothrops lanceolatus snakebite envenoming: Crude venom-induced reduction of in vitro enzymatic activity and clinical correlation in snakebite patients.

PLoS Neglected Tropical Diseases
BackgroundEnvenoming by Bothrops lanceolatus, a viperid endemic to Martinique an island in the Lesser Antilles, induces a unique clinical manifestation, i.e., thrombosis. Pathophysiological signaling leading to thrombotic events remains poorly understood.
Jonathan Florentin, Caroline Rapon, Olivier Pierre-Louis, Fatima Radouani, Prisca Jalta, Pascal Fuseau, Hatem Kallel, Remi Neviere, Dabor Resiere   +8 more
doaj   +1 more source

Long Term Follow Up of Hereditary Thrombotic Thrombocytopenic Purpura on Plasma Therapy for 9 Years: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT A 7.6‐year‐old boy with hTTP had fever‐induced hemorrhagic rash, MAHA, cerebral infarction, and renal impairment. After plasma therapy, symptoms were partially relieved; 9‐year follow‐up showed regular plasma transfusion was needed, with CKD Stage 3.
Dai Xiaomei, Chen Ruyue, Wu Shuang, Tang Hanyun, Lin Qiang, Li Xiaozhong   +5 more
wiley   +1 more source

Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura. [PDF]

BACKGROUND Congenital thrombotic thrombocytopenic purpura (TTP) results from severe hereditary deficiency of ADAMTS13. The efficacy and safety of recombinant ADAMTS13 and standard therapy (plasma-derived products) administered as routine prophylaxis ...
Xiao, Shan, Cataland, Spero R, Kremer Hovinga, Johanna A, López-Fernández, M Fernanda, Hassenpflug, Wolf-Achim, Zhang, Pinghai, Scully, Marie, Ortel, Thomas L, Coppo, Paul, Dossier, Claire, Bhattacharya, Indranil, Cronin, Michael, Matsumoto, Masanori, Mellgård, Björn, Patwari, Parth, Patel, Munjal, Li, Hong, Biebuyck, Nathalie, Kentouche, Karim, Knöbl, Paul, Antun, Ana, Windyga, Jerzy, Wang, Linda T   +22 more
core   +1 more source

Cloning, Expression and Inhibitory Effects on Lewis Lung Carcinoma Cells of rAj-Tspin from Sea Cucumber (Apostichopus japonicus)

Molecules, 2021
In recent years, sea cucumber has become a favorite healthcare food due to its characteristic prevention of cardiovascular diseases, suppression of tumors, as well as enhancement of immunity.
Rong Qiao, Rong Xiao, Zhong Chen, Jingwei Jiang, Chenghua Yuan, Shuxiang Ning, Jihong Wang, Zunchun Zhou   +7 more
doaj   +1 more source

Plasma Exchange for Hantavirus Pulmonary Syndrome: A Mechanistic Case for an Untested Intervention

Journal of Clinical Apheresis, Volume 41, Issue 5, October 2026.
ABSTRACT Hantavirus pulmonary syndrome (HPS) carries a case fatality rate of 35%–40% and has no approved pharmacologic treatment. Its pathophysiology is rooted in the plasma compartment: cytokines, viral antigens, immune complexes, and platelet‐binding glycoproteins circulate as drivers of immunopathologic endothelial injury, noncardiogenic pulmonary ...
Menatalla Nadim, Yasamin Mirzabeigi, Yamac Akgun   +2 more
wiley   +1 more source

ADAMTS13 expression detected intracellularly by immunofluorescence.

, 2013
ADAMTS13 protein expression was investigated in CiGEnC (panels A–B) and HMVEC (panels C–D). ADAMTS13 was detected in CiGEnC using SU19 polyclonal antibody (panel A).
David Motto (349293), Matthias Mörgelin (109607), Anne-lie Ståhl (349291), Minola Manea-Hedström (349298), Peter Mathieson (349296), Diana Karpman (67915), Ramesh Tati (349287), Simon Satchell (349295), Ann-Charlotte Kristoffersson (349289)   +8 more
core   +1 more source

Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease

MedComm, Volume 7, Issue 10, October 2026.
NETs as integrated effectors in the atherosclerotic cardiovascular disease continuum. Activated neutrophils release NETs that promote endothelial injury, thrombo‐inflammation, and plaque destabilization throughout atherosclerotic disease progression. Created with BioRender.com.
Ji Zhang, Fangjiaqi Wei, Mengdi Qu, Yuwen Shao, Tingye Xu, Darko Stojkov, Hans‐Uwe Simon, Ben Huang, Changhong Miao, Hao Zhang   +9 more
wiley   +1 more source

PROTEOLYTIC PROCESSING OF VON WILLEBRAND FACTOR BY ADAMTS13 AND LEUKOCYTE PROTEASES

Mediterranean Journal of Hematology and Infectious Diseases, 2013
ADAMTS13 is a 190 kDa zinc protease encoded by a gene located on chromosome 9q34.   This protease specifically hydrolyzes von Willebrand factor (VWF) multimers, thus causing VWF size reduction.
Stefano Lancellotti, Maria Basso, Raimondo De Cristofaro   +2 more
doaj   +1 more source

ADAMTS13, an Anti-thrombotic Protein: Evidence Outside of Thrombotic Thrombocytopenic Purpura

Blood, 2019
von Willebrand factor (VWF) is a large multimeric plasma glycoprotein that plays a crucial role in hemostasis and thrombosis. VWF recruits platelets at sites of vascular injury by acting as a molecular bridge between circulating platelets and the site of injured or activated blood vessels.
openaire   +1 more source