Results 91 to 100 of about 8,844 (195)
Aging Cell, Volume 25, Issue 4, April 2026.A 14‐protein extracellular matrix aging clock derived from circulating matrisome proteins predicts chronological and biological age across cohorts and biofluids, distinguishes health from disease, and is modulated by rejuvenation interventions in mice, enabling the nomination of potential ECM targets for drug discovery to promote healthy aging ...
Loet Coenen +4 more
wiley +1 more source
Scientific ReportsMesenchymal stem cells (MSCs) are known to facilitate angiogenesis and promote neo-vascularization via secretion of trophic factors. Here, we explored the molecular mechanism adopted by ADAMTS13 in modulating the expression of some key angiogenic markers
Srishti Dutta Gupta, Malancha Ta
doaj +1 more source
Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity. [PDF]
PLoS ONE, 2011 Von Willebrand factor (VWF) is a pro-hemostatic multimeric plasma protein that promotes platelet aggregation and stabilizes coagulation factor VIII (FVIII) in plasma.
Martine J Hollestelle +6 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT Osteosarcoma (OS) is an aggressive primary bone tumour with high metastatic potential. Current treatments including surgery and chemotherapy are limited by side effects and chemoresistance, underscoring the need for novel therapies. This study aimed to investigate the antitumor potential of resveratrol (RSV), a natural polyphenol, as a novel ...
Raffaella De Pace +6 more
wiley +1 more source
Scientific ReportsImmune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and life-threatening blood disorder characterized by the formation of blood clots in small blood vessels. It is caused by antibodies targeting the A disintegrin and metalloprotease with
Heechun Kwak +13 more
doaj +1 more source
The diagnosis and management of the haematologic manifestations of lupus [PDF]
, 2016 Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe.
Castro, SG +2 more
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Von Willebrand factor (VWF) and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13) are linked to dementia risk, and limited evidence suggests apolipoprotein E (APOE)‐ε4 alters VWF release.
Hailey A. Adegboye +22 more
doaj +1 more source
Internal tension in a collapsed polymer under shear flow and the connection to enzymatic cleavage of von Willebrand factor [PDF]
, 2016 By means of Brownian hydrodynamics simulations we show that the tension distribution along the contour of a single collapsed polymer in shear flow is inhomogeneous and above a threshold shear rate exhibits a double-peak structure when hydrodynamic ...
Lippok, Svenja +3 more
core +2 more sources
Current Issues in Molecular BiologyGenetic and epigenetic alterations of various biomolecules at the molecular level can contribute to the pathogenesis of hepatocellular carcinoma (HCC) and negative impact prognosis.
Durmuş Ayan +5 more
doaj +1 more source
Atypical hemolytic uremic syndrome : update on the complement system and what is new [PDF]
, 2010 Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic anemia, thrombocytopenia, and predominant renal impairment. It is characterized by the absence of Shiga toxin-producing bacteria as a triggering factor.
Dickenmann, Michael +2 more
core +1 more source