Results 131 to 140 of about 5,721 (151)

Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population: A cross-sectional study

Clinica Chimica Acta, 2013
Although a defect in ADAMTS13 activity is known to cause platelet thrombosis resulting in thrombotic thrombocytopenic purpura (TTP), recent evidence has revealed that low plasma ADAMTS13 concentrations may increase the risk of ischemic vascular diseases.
Kenichiro Enooku, Reiko Kato, Kenichi Aizawa   +2 more
exaly   +3 more sources

Simvastatin Improve ADAMTS13 mRNA and Protein Expression in Podocytes.

Blood, 2012
Abstract Abstract 2246 Aim: ADAMTS13 is a specific VWF (von Willebrand factor) -cleaving protease, which severe deficiency is the main cause of thrombotic thrombocytopenic purpura. ADAMTS13 is mainly synthesized and released of the surface of hepatic stellate cells and endothelial cells,
Lei Shen, Guoyuan Lu, Ningzheng Dong, Zhenni Ma, Changgeng Ruan   +4 more
openaire   +1 more source

Hematocrit and C‐reactive protein predict treatment response times in ADAMTS13‐deficient thrombotic microangiopathy

Journal of Clinical Apheresis, 2011
AbstractThrombotic microangiopathy (TMA) syndromes are a heterogeneous group of microvascular syndromes that are typically treated with plasma exchange and other adjunctive therapies. Important pathogenic factors, such as ADAMTS13 deficiency, define distinct subsets of TMA.
Noelle I, Samia, Kenneth D, Friedman, Jerome L, Gottschall, Thomas J, Raife   +3 more
openaire   +2 more sources

Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation

Heart and Vessels, 2008
The aim of the present study is to clarify the roles of circulating ADAMTS13 and von Willebrand factor (VWF) in the formation of coronary artery thrombi in acute myocardial infarction (AMI). Twenty-six AMI patients, 37 age-matched healthy controls, and 20 young controls were studied.
Manabu, Horii, Shiro, Uemura, Masahito, Uemura, Masanori, Matsumoto, Hiromichi, Ishizashi, Keiichi, Imagawa, Hajime, Iwama, Yukiji, Takeda, Hiroyuki, Kawata, Tamio, Nakajima, Yoshihiro, Fujimura, Yoshihiko, Saito   +11 more
openaire   +2 more sources

High-Throughput Screening of a Large Combinatorial Library of Small Proteins Against Human Spleen-Derived Monoclonal Anti-ADAMTS13 Antibodies Yields Specific Anti-Idiotypic Molecules – Potential Tools for New Treatment Strategy in Acquired TTP

Blood, 2012
Abstract Abstract 487 Background. Acquired Thrombotic Thrombocytopenic Purpura (TTP) is the result of autoantibodies (Abs) neutralizing and/or accelerating clearance of ADAMTS13. Despite the first-line treatment with daily plasma exchange (PEX), acute TTP is still associated with a ...
Schaller, Monica, Hiltbrunner, Sabine, Sulzer, Irmela, Vogel, Monique, Kentouche, Karim, Laemmle, Bernhard, Hovinga, Johanna A. Kremer   +6 more
openaire   +2 more sources

[Effect of Recombinant Protein in the Spacer Domain on ADAMTS13 Activity].

Zhongguo shi yan xue ye xue za zhi, 2019
To obtain the recombinant protein of spacer domain in von Willebrand factor cleaving protease (ADAMTS13), and further study its biological function in ADAMTS13.The prokaryotic expression vector was constructed by using the template of plasmid with full-length ADAMTS13, and then transfected into E coli., following the induction of IPTG with the low ...
Zhen-Ni, Ma, Jing, Ling, Jie, Yin, Fei, Shen, Jian, Su, Li-Qian, Xie, Chang-Geng, Ruan   +6 more
openaire   +1 more source

Arginine Methylation on ADAMTS13 By Protein Arginine Methyltransferase 1 (PRMT1) Affects ADAMTS13 Secretion and Proteolytic Activity

Blood, 2022
Szumam Liu, Xinyang Zhao, X. Long Zheng
openaire   +1 more source

An interactive database containing all known variants in ADAMTS13 yields new insight into the genetic variation and protein changes underlying congenital TTP

Blood
Abstract Introduction A disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS13) is encoded by a 45kb gene on chromosome 9q34.2. Deficiency leads to Thrombotic Thrombocytopenic Purpura (TTP), which exists as immune TTP (iTTP), or congenital TTP (cTTP), an ...
Matthew Carter, Imogen Buckle, Stephen Perkins, Marie Scully   +3 more
openaire   +1 more source

Factor VIII/protein C and not ADAMTS13/VWF:Ag ratio is a prognostic risk factor for patients with cirrhosis and low MELD score

Journal of Hepatology, 2020
N. Bitto, G. Tosetti, A. Tripodi, I. Mancini, L. Baronciani, C. Valsecchi, P. Lampertico, F. Peyvandi, M. Primignani, V. La Mura   +9 more
openaire   +1 more source