mRNA treatment produces sustained expression of enzymatically active human ADAMTS13 in mice
Scientific Reports, 2018 Thrombotic thrombocytopenic purpura (TTP) is primarily caused by deficiency of ADAMTS13 within the blood stream due to either genetic defects or presence of inhibitory autoantibodies.
Susan Liu-Chen +4 more
semanticscholar +1 more source
Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS) [PDF]
, 2004 Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS).BackgroundThrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS) are now considered to be variants of one single syndrome ...
Budde, Ulrich +5 more
core +1 more source
Plasma von Willebrand factor levels predict in-hospital survival in patients with acute-on-chronic liver failure [PDF]
, 2016 BACKGROUND AND AIMS: Circulating levels of von Willebrand factor (vWF) predict mortality in patients with cirrhosis. We hypothesized that systemic inflammation in acute-on-chronic liver failure (ACLF) will stimulate endothelium, increase vWF levels, and ...
Amirtharaj, GJ +9 more
core +1 more source
The diagnosis and management of the haematologic manifestations of lupus [PDF]
, 2016 Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe.
Castro, SG +2 more
core +1 more source
Anemia, 2011 Sickle cell anemia (SCA) is a common hemolytic disorder caused by a gene mutation in the β-globin subunit of hemoglobin (Hb) and affects millions of people.
Zhou Zhou +2 more
doaj +1 more source
Develop machine learning based predictive models for engineering protein solubility [PDF]
arXiv, 2018 Protein activity is a significant characteristic for recombinant proteins which can be used as biocatalysts. High activity of proteins reduces the cost of biocatalysts. A model that can predict protein activity from amino acid sequence is highly desired, as it aids experimental improvement of proteins.
arxiv
Analysis of interactions between inflammatory and vasoregulatory pathways in chronic heart failure: application of logical analysis of data, a novel data-mining tool = Analysis of interactions between inflammatory and vasoregulatory pathways in chronic heart failure: application of logical analysis of data, a novel data-mining tool [PDF]
, 2012 Pályázatunk keretein belül a következő feladatokat valósítottuk meg: 1, Klinikai vizsgálatokat tervezetünk és kiviteleztünk szívelégtelenségben, tüdőgyulladás eredetű szepszisben, preeclampsiában és colorectalis carcinomában szenvedő betegek ...
Aladzsity, István +9 more
core
A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13 [PDF]
, 2017 In this case report, we describe for the first time a patient with thrombotic thrombocytopaenic purpura (TTP) accompanying highly active systemic lupus erythematosus (SLE) that was associated with non-neutralizing antibodies against the plasma ...
Ferrari, Silvia +4 more
core
An Unusual Case of Rapidly Progressive Hyperbilirubinemia
Case Reports in Pediatrics, 2013 We present an unusual case of hyperbilirubinemia with rapid early progression leading to bilirubin encephalopathy in a term neonate. Despite early recognition and intervention, the total serum bilirubin reached a maximum level of 39 mg/dL at 32 hours of ...
Kimberly M. Thornton +7 more
doaj +1 more source
Rare Variants in the ADAMTS13 Von Willebrand Factor–Binding Domain Contribute to Pediatric Stroke
Circulation: Cardiovascular Genetics, 2016 Background—Recently, we reported a gene network of ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) genes as central component of the genetic risk contributing to pediatric stroke.
M. Stoll +6 more
semanticscholar +1 more source