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From dog bite to dialysis: complement-mediated haemolytic uraemic syndrome . [PDF]

BMJ Case Rep
Fredriksen TE, Mian BU, Dolgos S.
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Rapid ADAMTS13 activity assays for thrombotic thrombocytopenic purpura: a systematic review and meta-analysis.

Blood
Deshpande SR, Tarawneh H, Deitelzweig C, Tong J, Zhou T, Chen Y, Cuker A.   +6 more
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Simvastatin Improve ADAMTS13 mRNA and Protein Expression in Podocytes.

Blood, 2012
Abstract Abstract 2246 Aim: ADAMTS13 is a specific VWF (von Willebrand factor) -cleaving protease, which severe deficiency is the main cause of thrombotic thrombocytopenic purpura. ADAMTS13 is mainly synthesized and released of the surface of hepatic stellate cells and endothelial cells,
Lei Shen, Guoyuan Lu, Ningzheng Dong, Zhenni Ma, Changgeng Ruan   +4 more
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Hematocrit and C‐reactive protein predict treatment response times in ADAMTS13‐deficient thrombotic microangiopathy

Journal of Clinical Apheresis, 2011
AbstractThrombotic microangiopathy (TMA) syndromes are a heterogeneous group of microvascular syndromes that are typically treated with plasma exchange and other adjunctive therapies. Important pathogenic factors, such as ADAMTS13 deficiency, define distinct subsets of TMA.
Noelle I, Samia, Kenneth D, Friedman, Jerome L, Gottschall, Thomas J, Raife   +3 more
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Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation

Heart and Vessels, 2008
The aim of the present study is to clarify the roles of circulating ADAMTS13 and von Willebrand factor (VWF) in the formation of coronary artery thrombi in acute myocardial infarction (AMI). Twenty-six AMI patients, 37 age-matched healthy controls, and 20 young controls were studied.
Manabu, Horii, Shiro, Uemura, Masahito, Uemura, Masanori, Matsumoto, Hiromichi, Ishizashi, Keiichi, Imagawa, Hajime, Iwama, Yukiji, Takeda, Hiroyuki, Kawata, Tamio, Nakajima, Yoshihiro, Fujimura, Yoshihiko, Saito   +11 more
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Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population: A cross-sectional study

Clinica Chimica Acta, 2013
Although a defect in ADAMTS13 activity is known to cause platelet thrombosis resulting in thrombotic thrombocytopenic purpura (TTP), recent evidence has revealed that low plasma ADAMTS13 concentrations may increase the risk of ischemic vascular diseases.
Kenichiro, Enooku, Reiko, Kato, Hitoshi, Ikeda, Makoto, Kurano, Yukio, Kume, Haruhiko, Yoshida, Tomoko, Ono, Kenichi, Aizawa, Toru, Suzuki, Tsutomu, Yamazaki, Yutaka, Yatomi   +10 more
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High-Throughput Screening of a Large Combinatorial Library of Small Proteins Against Human Spleen-Derived Monoclonal Anti-ADAMTS13 Antibodies Yields Specific Anti-Idiotypic Molecules – Potential Tools for New Treatment Strategy in Acquired TTP

Blood, 2012
Abstract Abstract 487 Background. Acquired Thrombotic Thrombocytopenic Purpura (TTP) is the result of autoantibodies (Abs) neutralizing and/or accelerating clearance of ADAMTS13. Despite the first-line treatment with daily plasma exchange (PEX), acute TTP is still associated with a ...
Monica Schaller, Sabine Hiltbrunner, Irmela Sulzer, Monique Vogel, Karim Kentouche, Bernhard Laemmle, Johanna A. Kremer Hovinga   +6 more
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