Results 21 to 30 of about 5,511,471 (226)

ADAMTS13 regulates angiogenic markers via Ephrin/Eph signaling in human mesenchymal stem cells under serum-deprivation stress

Scientific Reports
Mesenchymal stem cells (MSCs) are known to facilitate angiogenesis and promote neo-vascularization via secretion of trophic factors. Here, we explored the molecular mechanism adopted by ADAMTS13 in modulating the expression of some key angiogenic markers
Srishti Dutta Gupta, Malancha Ta
doaj   +2 more sources

The Intriguing Relationships of von Willebrand Factor, ADAMTS13 and Cardiac Disease

Journal of Cardiovascular Development and Disease, 2021
von Willebrand factor (VWF) is an adhesive protein involved in primary hemostasis and facilitates platelet adhesion to sites of vascular injury, thereby promoting thrombus formation. VWF exists in plasma as multimers of increasing size, with the largest (
Benjamin Reardon, Leonardo Pasalic, Emmanuel J. Favaloro   +2 more
doaj   +2 more sources

Shedding Light on the Possible Link between ADAMTS13 and Vaccine—Induced Thrombotic Thrombocytopenia

Cells, 2021
Several recent reports have highlighted the onset of vaccine-induced thrombotic thrombocytopaenia (VITT) in some recipients (approximately 1 case out of 100k exposures) of the ChAdOx1 nCoV-19 vaccine (AstraZeneca).
Anna Szóstek-Mioduchowska, Paweł Kordowitzki   +1 more
doaj   +2 more sources

Hereditary Thrombotic Thrombocytopenic Purpura in a Chinese Boy With a Novel Compound Heterozygous Mutation of the ADAMTS13 Gene

Frontiers in Pediatrics, 2020
Hereditary thrombotic thrombocytopenic purpura (TTP) is caused by ADAMTS13 mutations with autosomal recessive inheritance. It typically presents during childhood and is frequently misdiagnosed as immune thrombocytopenia.
Yi-ling Dai, Yi-ling Dai, Xue Tang, Xue Tang, Hong-bo Chen, Hong-bo Chen, Qiu-yu Peng, Qiu-yu Peng, Xia Guo, Xia Guo, Ju Gao, Ju Gao   +11 more
doaj   +2 more sources

Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS [PDF]

Blood Advances
: Allosteric regulation of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type-1 motif, member 13) activity involves an interaction between its spacer (S) and 2 complement C1r/C1s, Uegf and BMP1 (CUB; CUB1-2) domains to keep the enzyme
Quintijn Bonnez, Emily R. Legan, Inge Pareyn, Febe Boudry, Jennifer Anckaert, Claudia Tersteeg, Simon F. De Meyer, Renhao Li, Karen Vanhoorelbeke   +8 more
doaj   +2 more sources

Management of congenital thrombotic thrombocytopenic purpura in the era of recombinant ADAMTS13 protein: Recommendations from the Reference Center for Thrombotic Microangiopathies (CNR-MAT)

La Revue de medecine interne
Thrombotic Thrombocytopenic Purpura (TTP) is a rare disease characterized by a severe deficiency of ADAMTS13, the specific protease that cleaves von Willebrand factor. The congenital form of TTP (cTTP) results from pathogenic variants of the ADAMTS13 gene.
Joly, Bérangère S., Veyradier, Agnès, Coppo, Paul, Joseph, Adrien, Dossier, Claire, Kwon, Theresa, Gouge-Biebuyck, Nathalie, Boyer, Olivia, Tsatsaris, Vassilis   +8 more
openaire   +2 more sources

Arginine Methylation on ADAMTS13 By Protein Arginine Methyltransferase 1 (PRMT1) Affects ADAMTS13 Secretion and Proteolytic Activity

Blood, 2022
Szumam Liu, Xinyang Zhao, X. Long Zheng
openaire   +2 more sources

Factor VIII/protein C and not ADAMTS13/VWF:Ag ratio is a prognostic risk factor for patients with cirrhosis and low MELD score

Journal of Hepatology, 2020
Carla Valsecchi, Luciano Baronciani, I. Mancini, V. La Mura, Pietro Lampertico, Armando Tripodi, Flora Peyvandi, Giulia Tosetti, Niccolò Bitto, Massimo Primignani   +9 more
  +5 more sources

A Thrombocytopenic Thrombotic Purpura in a Patient With a Metastatic HER2+ Breast Cancer: Description of a Case Report. [PDF]

Clin Case Rep
ABSTRACT Paraneoplastic (p) TTP is a rare syndrome characterized by an immune‐induced, generalized microangiopathy associated with solid or hematological tumors. This case, reporting a patient with a metastatic HER2+ breast cancer and a pTTP, highlights the rarity of this entity, its difficult and challenging diagnosis, and the complexity of its ...
Longo R, Savenkoff B, Ribal R, Dadoun A, Campitiello M, Plastino F, Legros PO, Marcon N, Coppo P, Egea J.   +9 more
europepmc   +2 more sources

Dexmedetomidine Reduces Chronic Stress-Related Thrombosis in a Mouse FeCl₃ Model. [PDF]

FASEB J
Schematic summary of the mechanism by which dexmedetomidine prevents chronic stress–related carotid artery thrombosis in a mouse FeCl3 model. These findings present evidence and a potential mechanistic explanation of the Dex‐mediated amelioration of arterial thrombosis associated with the reduction of oxidative stress, inflammation, and apoptosis, and ...
Wang H, Zhang M, Xin M, Yue X, Piao J, Zhao L, Bi H, Wang S, Jin C, Nan Y, Jin X, Cheng XW.   +11 more
europepmc   +2 more sources