Results 101 to 110 of about 4,702 (188)

Collagen II enrichment through scAAV6-RNAi-mediated inhibition of matrix-metalloproteinases 3 and 13 in degenerative nucleus-pulposus cells degenerative disc disease and biological treatment strategies

Experimental Biology and Medicine
Intervertebral disc (IVD) degeneration damaging the extracellular matrix (ECM) of IVDs is the main cause of spine-associated disorders. Degenerative disc disease (DDD) is a multifaceted disorder, where environmental factors, inflammatory cytokines and ...
Demissew Shenegelegn Mern, Claudius Thomé   +1 more
doaj   +1 more source

Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs

JOR Spine
Background Intervertebral disc degeneration involves aging and senescence of nucleus pulposus cells (NPCs), and JAK/STAT signaling may contribute to this process.
Honggang Hao, Weidong Liang, Shuwen Zhang, Xiaoyu Cai, Abulizi Yakefu, Shutao Gao, Chuanhui Xun, Tao Xu, Rui Cao, Weibin Sheng   +9 more
doaj   +1 more source

A novel association between TGFβ1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes [PDF]

Objective: Coronary artery disease is characterized by atherosclerosis in the vessel wall. Recently, it has been thought that increasing LDL-binding capacity of subendothelial proteoglycan fragments that are formed by protease activity can be responsible
Uluçay, S, Çam, FS, Batir, MB, Bayturan, Ö, Demircan, K, Sütçü, R   +5 more
core  

Dynamics of N6‐methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc

JOR Spine
Background The N6‐methyladenosine (m6A) dynamics in the progression of intervertebral disc (IVD) aging remain largely unknown. This study aimed to explore the distribution and pattern of m6A modification in nucleus pulpous (NP) tissues of rats at ...
Libangxi Liu, Hong Sun, Yang Zhang, Chang Liu, Yong Zhuang, Miao Liu, Xuezheng Ai, Dan Long, Bo Huang, Changqing Li, Yue Zhou, Shiwu Dong, Chencheng Feng   +12 more
doaj   +1 more source

Therapeutic potential of dedifferentiated fat cells in a rat model of osteoarthritis of the knee

Regenerative Therapy
Introduction: Mature adipocyte-derived dedifferentiated fat cells (DFATs) represent a subtype of multipotent cells that exhibit comparable phenotypic and functional characteristics to adipose-derived stem cells (ASCs).
Noriyuki Endo, Taro Matsumoto, Tomohiko Kazama, Koichiro Kano, Manabu Shimizu, Keinosuke Ryu, Yasuaki Tokuhashi, Kazuyoshi Nakanishi   +7 more
doaj   +1 more source

The metalloprotease ADAMTS4 generates N-truncated A4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease [PDF]

Brain accumulation and aggregation of amyloid- (A) peptides is a critical step in the pathogenesis of Alzheimer's disease (AD). Full-length A peptides (mainly A1-40 and A1-42) are produced through sequential proteolytic cleavage of the amyloid precursor ...
Huettenrauch, Melanie, Walter, Susanne, Pietrzik, Claus U., Lepka, Klaudia, Storck, Steffen E., Dimitrov, Mitko, Jumpertz, Thorsten, Lehmann, Sandra, Becker-Pauly, Christoph, Wirths, Oliver, Zampar, Silvia, Berndt, Carsten, Beher, Dirk, Ogorek, Isabella, Gerber, Hermeto, Weggen, Sascha, Wiltfang, Jens, Fraering, Patrick C.   +17 more
core   +1 more source

Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5,

, 2019
Aim To test the hypothesis that altered A Disintegrin and Metalloproteinase Domains with Thrombospondins motifs (ADAMTS) is implicated in the etiopathogenesis of gestational diabetes mellitus (GDM). Methods All pregnant women who underwent elective amniocentesis for karyotype analysis between January 1, 2016, and January 1, 2018, were included in this ...
Melekoglu, R, Ciftci, O, Celik, E, Yilmaz, E, Bastemur, AG   +4 more
openaire  

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease [PDF]

, 2019
Brain accumulation and aggregation of amyloid-β (Aβ) peptides is a critical step in the pathogenesis of Alzheimer’s disease (AD). Full-length Aβ peptides (mainly Aβ1–40 and Aβ1–42) are produced through sequential proteolytic cleavage of the amyloid ...
Walter, Susanne, Pietrzik, Claus U., Lepka, Klaudia, Storck, Steffen E., Dimitrov, Mitko, Jumpertz, Thorsten, Lehmann, Sandra, Becker-Pauly, Christoph, Wirths, Oliver, Zampar, Silvia, Berndt, Carsten, Beher, Dirk, Ogorek, Isabella, Gerber, Hermeto, Hüttenrauch, Melanie, Wiltfang, Jens, Fraering, Patrick C.   +16 more
core  

479 THE REGULATION OF THE ADAMTS4 AND ADAMTS5 AGGRECANASES IN OSTEOARTHRITIS

Osteoarthritis and Cartilage, 2010
Bondeson, J., Wainwright, S.D., Hughes, C., Caterson, B.   +3 more
openaire   +1 more source

Modulation of ADAMTS4 via AAV gene therapy to modulate oligodendrocyte differentiation/maturation [PDF]

Spinal cord injury (SCI) is a growing epidemic with there being 45 cases per million people in NZ. Patients affected by this disease have impairments in the functionality of normal spinal cord physiology, leading to impaired sensory, motor and autonomic ...
Young, Calvin
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