Results 91 to 100 of about 4,702 (188)

Chromobox 3 assembles an epigenetic complex contributing to cystathionine γ-lyase–mediated protection against aortic aneurysm/dissection

Nature Communications
Hydrogen sulfide (H₂S), generated by cystathionine γ-lyase (CSE), protects against aortic aneurysm and dissection (AAD), yet its role in extracellular matrix (ECM) regulation remains unclear.
Ying Zhao, Changting Cui, Huimin Gao, Yan Yao, Yaping Niu, Ling Cheng, Xiaodie Shao, Haizeng Zhang, Yuan Wang, Yuanzhen Lin, Zengxiang Dong, He Wu, Zhenzhen Chen, Liming Yang, Bin Geng   +14 more
doaj   +1 more source

Digestion of chondroitin sulphate proteoglycans by AAV5-GfaABC1D-ADAMTS4 gene therapy enhances non-neuronal responses to contusive spinal injury. [PDF]

, 2022
Spinal cord injuries (SCI) are a dramatically impactful affliction of the central nervous system though to date no truly regenerative therapies exist.
Clemett, Connor A
core  

The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy

Journal of Experimental Orthopaedics, 2017
Background Synovial membrane inflammation is the most common finding presenting during hip arthroscopy, and may play a role in hip pain. We sought to determine the relationships between synovial cytokine levels, hip pain, and arthroscopic findings of the
Kensuke Fukushima, Gen Inoue, Hisako Fujimaki, Kentaro Uchida, Masayuki Miyagi, Naoshige Nagura, Katsufumi Uchiyama, Naonobu Takahira, Masashi Takaso   +8 more
doaj   +1 more source

The CNS-specific proteoglycan, brevican, and its ADAMTS4-cleaved fragment show differential serological levels in Alzheimer's disease, other types of dementia and non-demented controls: A cross-sectional study.

PLoS ONE, 2020
Evidence indicate that the brain-specific protein, brevican, is proteolytically cleaved during neurodegeneration, hence positioning fragments of brevican as potential blood biomarkers of neurodegenerative diseases, such as dementia.
Ditte S Jonesco, Morten A Karsdal, Kim Henriksen   +2 more
doaj   +1 more source

Decreased myocardial ADAMTS4 mRNA level after PPS-treatment. [PDF]

, 2014
Myocardial mRNA expression of ADAMTS4 in rats treated with PPS (n = 10) or vehicle (n = 7) six weeks after AB, and in sham-operated rats treated with PPS (n = 3) normalized to the reference gene RPL4 and relative to vehicle-treated sham (n = 3).
Jan Magnus Aronsen (347485), Ivar Sjaastad (162165), Cathrine R. Carlson (193912), Ida G. Lunde (193866), Geir Christensen (162197), Maria Vistnes (529698)   +5 more
core   +1 more source

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage [PDF]

European Cells & Materials, 2011
The relative contribution of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)4 and ADAMTS5 to aggrecan degradation under oncostatin M (OSM) stimulation, the role of the ancillary domains of the aggrecanases on their ability to ...
M Durigova, L Troeberg, H Nagase, PJ Roughley, JS Mort   +4 more
doaj  

ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain [PDF]

, 2002
Two major proteolytic cleavages, one at NITEGE(373)/A(374)RGSVI and the other at VDIPEN(341)/F(342)FGVGG, have been shown to occur in vivo within the interglobular domain of aggrecan.
Lavallie, ER, Sandy, JD, Hebert, T, Fosang, AJ, McDonagh, T, Westling, J, Last, K, Thompson, VP, Tomkinson, KN, Morris, EA, Collins-Racie, LA   +10 more
core   +1 more source

The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury

Journal of Neuroinflammation, 2012
Background Chondroitin sulfate proteoglycans are major inhibitory molecules for neural plasticity under both physiological and pathological conditions. The chondroitin sulfate degrading enzyme chondroitinase ABC promotes functional recovery after spinal ...
Tauchi Ryoji, Imagama Shiro, Natori Takamitsu, Ohgomori Tomohiro, Muramoto Akio, Shinjo Ryuichi, Matsuyama Yukihiro, Ishiguro Naoki, Kadomatsu Kenji   +8 more
doaj   +1 more source

The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression

Bone & Joint Research
Aims: cAMP response element binding protein (CREB1) is involved in the progression of osteoarthritis (OA). However, available findings about the role of CREB1 in OA are inconsistent.
Ying Wang, Zhimin Wu, Guoqiang Yan, Shan Li, Yanzhuo Zhang, Guangping Li, Chengai Wu   +6 more
doaj   +1 more source

Shaping Synapses by the Neural Extracellular Matrix

Frontiers in Neuroanatomy, 2018
Accumulating data support the importance of interactions between pre- and postsynaptic neuronal elements with astroglial processes and extracellular matrix (ECM) for formation and plasticity of chemical synapses, and thus validate the concept of a ...
Maura Ferrer-Ferrer, Alexander Dityatev, Alexander Dityatev, Alexander Dityatev   +3 more
doaj   +1 more source