Results 151 to 160 of about 4,702 (188)

Expression of ADAMTS4 (aggrecanase‐1) in human osteoarthritic cartilage

Pathology International, 2007
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)1, 4, 5, 8, 9 and 15, members of the ADAMTS gene family, have the ability to degrade a major cartilage proteoglycan, aggrecan, at the specific sites, and thus are called ‘aggrecanases’.
Yasunori Okada, Takayuki Shiomi
exaly   +3 more sources

ADAMTS4 and Oxidative/Antioxidative Status in Preterm Premature Rupture of Membranes

Fetal and Pediatric Pathology, 2016
To determine the function of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4), total oxidant status (TOS), total antioxidant status (TAS), and aryl esterase (ARES) in preterm premature rupture of membranes (PPROM) and to investigate the association with premature rupture of membranes (PROMs).58 pregnant women were included in ...
Dilek Şahin, Ozcan Bektaş, Aykan Yücel   +2 more
exaly   +4 more sources

Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4

Bioorganic Chemistry, 2018
The ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) enzyme is a matrix-associated zinc metalloendopeptidase that plays an essential role in the degradation of cartilage aggrecan in arthritic diseases and has been recognized as one of the most primary targets for therapeutic intervention in osteoarthritis (OA).
Congfeng Luo, Shang Guo, Chi Zhang
exaly   +3 more sources

ADAMTS4 [PDF]

, 2013
The subject of this chapter is ADAMTS4. ADAMTS4 is a calcium-dependent metallo-endopeptidase homologous to the reprolysins. It is an ADAM protein that contains thrombospondin repeats.
Jan Bondeson, Shane Wainwright, Bruce Caterson, Clare Hughes   +3 more
openaire   +2 more sources

An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients [PDF]

Matrix Biology, 2006
The major proteoglycan of articular cartilage aggrecan is a substrate for ADAMTS4. RT-PCR analysis of human osteoarthritic (OA) synovial co-cultures using oligonucleotide primers designed to amplify across the exon 8/9 junction of human ADAMTS4 resulted ...
Clare Hughes, Jan Bondeson
exaly   +2 more sources

ADAMTS4 as an enzyme cleaving at APP669 site

Alzheimer's & Dementia, 2023
AbstractBackgroundWe have previously identified APP669‐711 (a.k.a. Aβ(‐3)‐40) in human plasma using immunoprecipitation combined with matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry (IP‐MALDI‐MS) (Kaneko et al., Proc Jpn Acad Ser B Phys Biol Sci. 2014).
Naoki Kaneko, Miyabishara Yokoyama, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamoto, Masaya Matsuzaki, Koichi Tanaka, Taisuke Tomita, Kentaro Ikemura, Gabriel Opoku, Satoshi Hirohata   +10 more
openaire   +1 more source

Inflammasome components and ADAMTS4 in premature rupture of membranes

Molecular Medicine Reports, 2020
Inflammation may be responsible for the development of premature rupture of membranes (PROM) including preterm PROM (PPROM) and mature PROM (MPROM). A total of four classic receptor proteins have been confirmed to assemble inflammasomes: NLR family pyrin domain containing (NLRP)1, NLRP3 and NLR family CARD‑domain containing 4 (NLRC4) and absent in ...
Jinming, Zhu, Chunling, Ma, Xiaomei, Luan, Juan, Li, Fengyun, Peng, Lei, Huang   +5 more
openaire   +2 more sources

Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase‐1) in osteoarthritic chondrocytes [PDF]

FEBS Letters, 2008
Aggrecanases that include ADAMTS1, 4, 5, 8, 9 and 15 are considered to play key roles in aggrecan degradation in osteoarthritic cartilage. Here we demonstrate that calcium pentosan polysulfate (CaPPS) directly inhibits the aggrecanase activity of ADAMTS4
Yasunori Okada
exaly   +2 more sources

Role of ADAMTS4 and ADAMTS5 during early orthodontic tooth movement. [PDF]

Journal of biological regulators and homeostatic agents, 2019
The aim of this study was to evaluate the expression of ADAMTS4 and ADAMTS5 in human gingivalcrevicular fluid (GCF) at different time-points following the application of an orthodontic force. Thirtytwohealthy patients (20 females, 12 males, mean age 13.8)
Muraglie, S, Musumeci, G, Loreto, C, Leonardi, R M   +3 more
openaire   +4 more sources

Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage [PDF]

Osteoarthritis and Cartilage, 2005
SummaryObjectiveTo investigate the mechanism of aggrecanolysis in interleukin-1 (IL-1)-treated cartilage tissue by examining the time course of aggrecan cleavages and the tissue and medium content of membrane type 4-matrix metalloproteinases (MT4-MMP ...
J D Sandy, A J Grodzinsky, J D Sandy
exaly   +2 more sources