Results 161 to 170 of about 4,702 (188)

Characterization of 5′-flanking region of human aggrecanase-1 (ADAMTS4) gene

Molecular Biology Reports, 2000
Aggrecanase-1, also known as ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4), cleaves at the Glu373-Ala374 site of aggrecan, thereby indicating aggrecan degradation. It is thought that ADAMTS4 plays a pivotal role in inflammatory joint diseases and cartilage degradation.
Y, Mizui, K, Yamazaki, Y, Kuboi, K, Sagane, I, Tanaka   +4 more
openaire   +2 more sources

The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.

Clinical and experimental rheumatology, 2008
Destruction of articular cartilage is a key feature of a number of arthritides, osteoarthritis prominent among them. Aggrecan degradation, caused by increased activity of proteolytic enzymes that degrade macromolecules in the cartilage extracellular matrix, is followed by irreversible collagen degradation.
J, Bondeson, S, Wainwright, C, Hughes, B, Caterson   +3 more
openaire   +1 more source

Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5

The FASEB Journal, 2018
ABSTRACT Osteoarthritis is a common disease in joint cartilages. Because the molecular pathogenesis of osteoarthritis remains elusive, early diagnostic markers and effective therapeutic agents have not been developed.
Yoshifumi, Takahata, Eriko, Nakamura, Kenji, Hata, Makoto, Wakabayashi, Tomohiko, Murakami, Kanta, Wakamori, Hiroshi, Yoshikawa, Akio, Matsuda, Naoshi, Fukui, Riko, Nishimura   +9 more
openaire   +2 more sources

Association of ADAMTS4 and ADAMTS9 levels with cardiovascular risk in patients with primary hyperparathyroidism

Endocrine Research, 2017
Primary hyperparathyroidism (PHPT) has been associated with increased incidence of morbidity and mortality of the cardiovascular system. The pathogenetic mechanisms underlying this association are still not completely clear. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) play a critical role in atherosclerosis.
Melia, Karakose, Mustafa, Caliskan, Muyesser Sayki, Arslan, Taner, Demirci, Suleyman, Karakose, Esra, Tutal, Erman, Cakal   +6 more
openaire   +2 more sources

Involvement of ADAMTS4 in membrane rupture at parturition

Placenta, 2023
Meng-die Li, Wang-sheng Wang, Gang Sun
openaire   +1 more source

Alzheimer Hastalığında ADAMTS4 Ve ADAM9 Proteinlerinin Rolü

2022
Alzheimer hastalığı (AD)’nda semptomlara değil, aynı zamanda hastalığın nedenlerine karşı etkili tedavilerin belirlenmesi zorunludur. Çalışmamızın amacı nöropatolojik lezyonları olduğu MRI ile belirlenmiş, ancak diğer demans sebepleri dışlanmış hastaların serumlarında, hastalıkla ilişkili olduğunu düşündüğümüz farklı sınıf metalloproteazların ...
Şehitoğlu, Hilal, Yılmaz, Mehmet Ali
openaire   +1 more source

Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

Biochimica Et Biophysica Acta - General Subjects, 2021
Takehiro Suzuki, Naoshi Dohmae, Kazuki Miura   +2 more
exaly  

Role of ADAMTS4 in Meningioma Bone Invasion

Journal of Neurological Surgery Part B: Skull Base, 2013
Takafumi Wataya, Shahrzad Jalali, Sidney Croul, Gelareh Zadeh   +3 more
openaire   +1 more source

DNA Methylation of the ADAMTS4 Gene in Jumper’s Knee

2015
Rickaby, Rebecca, Samiric, Tom, Raleigh, Stuart   +2 more
openaire   +1 more source

Astrocyte-selective AAV-ADAMTS4 gene therapy combined with hindlimb rehabilitation promotes functional recovery after spinal cord injury

Experimental Neurology, 2020
Alexandre Mouravlev, Connor Clemett, Jarred Griffin   +2 more
exaly