Results 101 to 110 of about 7,117 (194)
Expression of ADAMTS2 and ADAMTS5 in the salivary gland of rats after radioiodine therapy
Nuclear Medicine Communications, 2018 The aim of this study was to investigate the presence of ADAMTS2 and ADAMTS5 in the salivary gland (SG) of rats after high-dose radioiodine therapy.A total of 36 male Wistar albino rats were used for this study. Thirty-six male rats were divided randomly into six groups: control and five radioactive iodine (RAI) treatment groups of six rats each.
Sadic, Murat +7 more
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ADAMTS-5: The story so far [PDF]
European Cells & Materials, 2008 The recent discovery of ADAMTS-5 as the major aggrecanase in mouse cartilage came as a surprise. A great deal of research had focused on ADAMTS-4 and much less was known about the regulation, expression and activity of ADAMTS-5. Two years on, it is still
A J Fosang +3 more
doaj
Genotyping the ADAMTS5-P (Pfizer) mouse strain v1 [PDF]
, 2017 ADAMTS5, the main aggrecanase, is a protein that seems to play a functional role in the development of brown and white adipose tissue (WAT) and browning of WAT. These published observations were made using the ADAMTS5-P mice originally generated by Pfizer, in collaboration with Lexicon Genetics (The Woodlands, TX, USA).
Bianca Hemmeryckx +2 more
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Substantive molecular and histological changes within the meniscus with tears
BMC Musculoskeletal Disorders, 2019 Background The meniscus plays a vital role in the normal biomechanics of the knee. However, it is not well studied at the molecular level. The purpose of this study was to determine whether molecular and pathological changes in the meniscal tissue vary ...
Yi Long +5 more
doaj +1 more source
Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis
Cell Communication and SignalingThe proinflammatory cytokines and arachidonic acid (AA)-derived eicosanoids play a key role in cartilage degeneration in osteoarthritis (OA). The lysophosphatidylcholine acyltransferase 3 (LPCAT3) preferentially incorporates AA into the membranes.
Vijay Kondreddy +4 more
doaj +1 more source
Zhongguo shiyan zhenduanxue, 2020 目的探究吉非替尼对兔膝骨性关节炎的病理特征及相关因子的影响。方法选取雌性新西兰大白兔60只,采用随机分组法将大白兔分为空白对照组、模型组、低剂量吉非替尼组和高剂量吉非替尼组各15只。除15只空白对照组,其他各组大白兔制成骨性关节炎(OA)模型,造模1周后,低剂量吉非替尼组使用4×10-1 mg/kg吉非替尼处理,高剂量吉非替尼组使用8×10-1 mg/kg吉非替尼处理。分别使用蛋白质印记法检测各组大白兔自噬蛋白Beclin1、LC3、p62表达情况;采用免疫荧光检测LC3含量 ...
谢大伟 +4 more
doaj
Materials & DesignTea polyphenols (Tp) have been reported to possess anti-inflammatory and antioxidant properties, but their application in osteoarthritis (OA) therapy is limited by poor bioavailability and lack of mechanistic clarity.
Yanchuan Pu +6 more
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In Vitro and in Silico Analysis of ADAMTS5 Transcription in Human Chondrocytes
Journal of Arthritis, 2013 Osteoarthritis is a major cause of disability in the adult population. Exercise is commonly prescribed, but the mechanisms underlying mechanotransduction of joint tissues are not well understood. Since Lrp5 is an important mechano-sensitive receptor in Wnt signaling, we examined its role in the mRNA expression of A Disintegrin and Metalloproteinase ...
openaire +1 more source
Intra-Articular Cyclo(His-Pro) Attenuates Monosodium Iodoacetate-Induced Osteoarthritis by Suppressing COX-2/PGE<sub>2</sub> Signaling and Cartilage Catabolism in Rats. [PDF]
Int J Mol SciHuh G, Lee D, Jeon J, Kim D, Jung HY.
europepmc +1 more source