Results 151 to 160 of about 7,117 (194)

Butin inhibits osteoarthritis progression by modulating the Nrf2/HO-1 signaling pathway and inhibiting NF-κB signaling. [PDF]

Sci Rep
Zhou P, Chang J, Wei X, Zhu C, Yang J, Wang C, Hu Y, Zhang C.   +7 more
europepmc   +1 more source

Immunomodulatory and anabolic biphasic scaffold with hierarchical biomimetic structure directed osteochondral defect repair. [PDF]

NPJ Regen Med
Yu H, Wang W, Wang H, Zhang W, Zheng Y, Chen L, Huang S, Yan W, Yao Q.   +8 more
europepmc   +1 more source

TAFA4 Mitigates Intervertebral Disc Degeneration by Modulating Macrophage Polarization and Inhibiting ROS-NLRP3 Inflammasome Activation. [PDF]

Neurospine
Han J, Huang J, Ding Z, Jiang Q, Yang G, Lu Z, Ma J, Zhang Y, Ding Y.   +8 more
europepmc   +1 more source

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ADAMTS5 promotes neovascularization via autophagic degradation of PEDF in proliferative diabetic retinopathy

Experimental Eye Research, 2023
Proliferative diabetic retinopathy (PDR) adversely affects visual function. Extracellular matrix proteins (ECM) contribute significantly to the development of PDR.
Jun Tan, Zhao Geng, Chongyi Li
exaly   +2 more sources

Characterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5

Journal of Biological Chemistry
A Disintegrin-like And Metalloprotease domain with Thrombospondin type I motifs (ADAMTS) 9 has essential, non-redundant roles during embryogenesis. Adamts9 null murine embryos die prior to completing gastrulation.
D. Martin, Gemma Sardelli, Tina Burkhard, M. M. Fowkes, AlexanderFrederick Minns, R. Moschini, Antonella Del Corso, Rens de Groot, Suneel S. Apte, Salvatore Santamaria   +9 more
semanticscholar   +5 more sources

ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Treponema pallidum Subspecies pallidum Invading the Central Nervous System

ACS Infectious Diseases
The pathogenesis of neurosyphilis remains unclear. A previous study found a noteworthy up-regulation of a disintegrin and metalloproteinase with thrombospondin type 1 motif 5 (ADAMTS5) gene in human brain microvascular endothelial cells cocultured with ...
Qianqiu Wang
exaly   +2 more sources

ADAMTS5

The American Journal of Pathology, 2012
This Commentary highlights the article by Kumar et al, showing that ADAMTS5 suppresses tumor growth by down-regulating other angiogenesis-inducing factors in addition to VEGF and that the central TSR1 domain of ADAMTS5 is required in this function.
Liisa Nissinen, Veli-Matti Kähäri
openaire   +3 more sources

Role of ADAMTS1 and ADAMTS5 in male infertility

Andrologia, 2016
The aim of this study was to investigate the relationship of infertility with metalloproteinases ADAMTS1 and ADAMTS5, which are known to be responsible for the degradation of extracellular matrix (ECM) proteins associated with many diseases. ECM is the noncellular component that provides structural and biochemical support to the surrounding cells ...
Aydos, S. E., Yukselten, Y., Sunguroglu, A., Demircan, K., Aydos, K.   +4 more
openaire   +2 more sources

ADAMTS5 is required for biomechanically‐stimulated healing of murine tendinopathy [PDF]

Journal of Orthopaedic Research, 2013
AbstractA recently developed murine model of tendinopathy, induced by TGF‐β1 injection, has been used to examine the reparative capacity of tendinopathic Achilles in Adamts5−/− mice. After TGF‐β1 injection and 2 weeks of treadmill exercise, the Achilles from Adamts5−/− mice exhibited a reduction in maximum tensile stress of approximately 60%.
Vincent Wang, Troy Kl
exaly   +3 more sources