Results 161 to 170 of about 7,117 (194)

Loss of ADAMTS5 promotes vascular calcification via versican/integrin β1/FAK signal.

Atherosclerosis
INTRODUCTION Extracellular matrix (ECM) proteases have been closely linked to the pathogenesis of vascular calcification. A disintegrin and metalloprotease with thrombospondin motifs-5 (ADAMTS5) is an ECM-degrading enzyme involved in ECM remodeling ...
Zhenyuan Zhu, Hao Liu, Liyun Feng, Lihe Lu, Jiahui Zhu, Qingchun Liang, Zirong Lan, Yuanzhi Ye, Siyi Wang, An Chen, Jianyun Yan   +10 more
semanticscholar   +1 more source

Computational Insights into ADAMTS4, ADAMTS5 and MMP13 Inhibitor Selectivity

Molecular Informatics, 2012
AbstractThe results obtained by means of Molecular Dynamics simulations and Multiway Explorative Data Analysis on ADAMTS4, ADAMTS5 and MMP13 complexed with Marimastat and two cis‐1(S)2(R)‐amino‐2‐indanol ligands suggest that determinant characteristics for ligand binding and selectivity among the three enzymes are to be found in the different protein ...
FILOMIA, Federico, SAXENA, PUNEET, DURANTE, Caterina, DE RIENZO, Francesca, COCCHI, Marina, MENZIANI, Maria Cristina   +5 more
openaire   +3 more sources

ADAMTS5 is required for normal trabeculated bone development in the mandibular condyle

Osteoarthritis and Cartilage, 2021
Determine the role of the extracellular matrix protease ADAMTS5 in development of the trabeculated bone of the mandibular condyle.The mandibular condyles of wild type and mice deficient in the protease ADAMTS5 were examined for histopathology with Safranin O staining.
A W, Rogers-DeCotes, S C, Porto, L E, Dupuis, C B, Kern   +3 more
openaire   +2 more sources

Role of ADAMTS5 in Unexplained Fetal Growth Restriction (FGR)

Fetal and Pediatric Pathology, 2016
We aim to determine the role of serum and placental A disintegrin and metalloproteinase with thrombospondin motif 5 (ADAMTS5) in fetal growth restriction (FGR).43 pregnancies suffering FGR and 45 healthy ones were homogenized for their body mass indices, ages, and gestational weeks.
Danisman, Nuri, Kadioglu, Nezaket, Oztas, Efser, Ozler, Sibel, Guler, Basak Gumus, Ergin, MERVE, Pehlivan, Sultan, Uygur, Dilek   +7 more
openaire   +3 more sources

The noncoding RNA linc-ADAMTS5 cooperates with RREB1 to protect from intervertebral disc degeneration through inhibiting ADAMTS5 expression

Clinical Science, 2017
Previous studies have indicated the important roles of ADAMTS5 in intervertebral disc degeneration (IDD). However, the mechanisms that regulate ADAMTS5 expression in nuclear pulposus (NP) cells remain largely unknown. Evidence suggests that intergenic transcription may be associated with genes that encode transcriptional regulators. Here, we identified
Kun, Wang, Yu, Song, Wei, Liu, Xinghuo, Wu, Yukun, Zhang, Shuai, Li, Liang, Kang, Ji, Tu, Kangcheng, Zhao, Wenbin, Hua, Cao, Yang   +10 more
openaire   +2 more sources

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Nature, 2005
Aggrecan is the major proteoglycan in cartilage, endowing this tissue with the unique capacity to bear load and resist compression. In arthritic cartilage, aggrecan is degraded by one or more 'aggrecanases' from the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteinases.
Heather, Stanton, Fraser M, Rogerson, Charlotte J, East, Suzanne B, Golub, Kate E, Lawlor, Clare T, Meeker, Christopher B, Little, Karena, Last, Pamela J, Farmer, Ian K, Campbell, Anne M, Fourie, Amanda J, Fosang   +11 more
openaire   +2 more sources

Investigation Roles of Adamts1 and Adamts5 in Scleral Fibroblasts under Hypoxia and Mice with Form-deprived Myopia.

Experimental Eye Research
Scleral hypoxia is considered a trigger in scleral remodeling-induced myopia. Identifying differentially expressed molecules within the sclera is essential for understanding the mechanism of myopia.
Ting Chen, Shanshan Liu, Zonglin Yang, Songfu Feng, Wanyi Fang, Xiaohe Lu, Jiali Li   +6 more
semanticscholar   +1 more source

Identification and validation of the TRHDE‐AS1/hsa‐miR‐449a/ADAMTS5 axis as a novel prognostic biomarker in prostate cancer

Biofactors
Despite advancements in cancer research, the prognostic implications of competing endogenous RNA (ceRNA) networks in prostate cancer (PCa) remain incompletely understood.
Xin Lian, Lei Pang, Hong Zhou, Si Liu
semanticscholar   +1 more source

ADAMTS5 Is a Biomarker for Prediction of Response to Infliximab in Patients with Rheumatoid Arthritis

The Journal of Rheumatology, 2010
Objective.To identify a biomarker for prediction of the response to infliximab (IFX) in patients with rheumatoid arthritis (RA), we focused on a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) that seems to play a key role in aggrecan degradation in cartilage.Methods.Seventy-three randomly selected patients with active RA were ...
Kensei, Tsuzaka, Yuka, Itami, Tsutomu, Takeuchi, Naoshi, Shinozaki, Tetsuo, Morishita   +4 more
openaire   +2 more sources

Identification of ADAMTS5 as APP‐Cleaving Enzyme at the APP669 Site

The FASEB Journal
Cerebral amyloid‐β (Aβ) deposition is a pathological hallmark of the earliest phases of Alzheimer disease (AD). We previously reported APP669‐711 as a novel Aβ‐related peptide detectable in human plasma and developed a composite biomarker that combines ...
Miyabishara Yokoyama, Honoka Kobayashi, Naoki Kaneko, Hiroki Naito, Kazushi Ota, Sadanori Sekiya, Kentaro Ikemura, Gabriel Opoku, Satoshi Hirohata, Shinichi Iwamoto, Koichi Tanaka, Taisuke Tomita   +11 more
semanticscholar   +1 more source