Results 151 to 160 of about 2,930,787 (173)

An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease. [PDF]

Aging Cell
Coenen L, Molière A, Lehallier B, Middeldorp J, Ewald CY.   +4 more
europepmc   +1 more source

Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis. [PDF]

Bioact Mater
He C, Huang G, Moradi L, Bi J, Yang X, Liu X, Cui X, Varthi A, Wiznia DH, Waxman SG, Fu W, Liu CJ.   +11 more
europepmc   +1 more source

The extracellular matrix-degrading protein ADAMTS5 is expressed in the nuclei of urothelial cells in healthy rats

Scandinavian Journal of Urology, 2018
The aim of this study was to investigate whether protein expression of the extracellular matrix-degrading protease ADAMTS5 can be demonstrated in the urinary bladder of healthy rats, and, if so, to determine the localization of this enzyme.The experiments were conducted with eight inbred male Sprague-Dawley rats.
Nikolai Scherbak, Rebecka Arnsrud Godtman, Magnus Fall   +2 more
exaly   +4 more sources

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ADAMTS5 Functions as an Anti-Angiogenic and Anti-Tumorigenic Protein Independent of Its Proteoglycanase Activity

American Journal of Pathology, 2012
ADAMTS5 is a member of the A Disintegrin-like And Metalloproteinase with ThromboSpondin motifs (ADAMTS) family of secreted metalloproteinases with multiple proteoglycan substrates. Although well characterized for its role in cartilage degradation and arthritis, how it influences cancer remains unclear.
Ge R, Saran Kumar
exaly   +3 more sources

IL-33 induces ADAMTS5 expression and cell migration in glioblastoma multiforme

Medical Oncology, 2022
Glioblastoma multiforme (GBM), characterized by a high rate of proliferation and migration capacity, is an incurable brain tumor in adults. Interleukin-33 (IL-33), a member of the IL-1 cytokine superfamily, and a disintegrin and metalloproteinase with ...
Asuman Sunguroğlu, Hasan Caglar Uğur, Yunus Yukselten   +2 more
exaly   +2 more sources

NF-ĸβ upregulates ADAMTS5 expression by direct binding after TNF-α treatment in OUMS-27 chondrosarcoma cell line

Molecular Biology Reports, 2020
Inflammation caused-aggrecan degradation is a critical event in the pathogenesis of osteoarthritis (OA). The aggrecanases like a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) are assumed to be key players in the aggrecan ...
Tülin Cora, Ömer Faruk Hatipoğlu, Dilek Gun Bilgic   +2 more
exaly   +2 more sources

Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5

Osteoarthritis and Cartilage, 2022
C B Little
exaly  

LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway

Bioengineered, 2021
Bo Yang, Hui Long
exaly  

Validation of the Diagnostic and Prognostic Values of ADAMTS5 and FSTL1 in Osteoarthritis Rat Model

Cartilage, 2021
Bakheet Elsadek, Sary Kh Abd-Elghaffar, Hafez R Madkor   +2 more
exaly