Results 71 to 80 of about 3,595,593 (336)
Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?
Mediators of Inflammation, 2015 Oxygen homeostasis reflects the constant body requirement to generate energy. Hypoxia (0.1–1% O2), physioxia or physoxia (∼1–13%), and normoxia (∼20%) are terms used to define oxygen concentration in the cellular environment.
H. Kumar, D. Choi
semanticscholar +1 more source
The Impact Of Spike-Frequency Adaptation On Balanced Network Dynamics [PDF]
, 2018 A dynamic balance between strong excitatory and inhibitory neuronal inputs is hypothesized to play a pivotal role in information processing in the brain.
Barranca, Victor J. +2 more
core +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Frontiers in Cellular and Infection Microbiology, 2017 Pseudomonas aeruginosa is an opportunistic pathogen affecting immunocompromised patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) patients and as one of the leading causes of nosocomial infections.
M. F. Moradali +2 more
semanticscholar +1 more source
An endogenous crepuscular rhythm of rainbow trout (Salmo gairdneri) photomechanical movements [PDF]
, 1982 1. The position of the epithelial pigment and cones in the retina of Salmo gairdneri was determined during extended periods of darkness in fish entrained to both artificial and natural light/dark cycles. 2. An endogenous rhythm of such photomechanical
Douglas, R. H.
core
Did Going North Give Us Migraine? An Evolutionary Approach on Understanding Latitudinal Differences in Migraine Epidemiology [PDF]
, 2019 This commentary discusses a recent publication by evolutionary biologists with strong implications for migraine experts. The Authors showed that a gene polymorphism associated with migraine gave our ancestors an evolutionary advantage when colonizing ...
Di Piero, V. +3 more
core +1 more source
Physiological adaptation in savanna ungulates [PDF]
Proceedings of the Nutrition Society, 1997 Savannas lie between the equatorial rain forests and the semi-deserts of the southern continents. From the herbivore’s viewpoint, the savanna environment is characterized by a mixture of herbaceous and woody vegetation, varying in quantity and growth stage according to the seasonal cycle of rainfall. C4 grasses (i.e.
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Ecophysiological adaptations of the lichen genera pseudocyphellaria and sticta to south temperate rainforests [PDF]
, 1991 Temperate rainforests are a poorly researched habitat with respect to lichen ecophysiology in comparison to desert and polar regions. The evergreen, broadleaf forests provide a dim, moist environment that is relatively stable throughout the year. Lichens
Green, T.G. Allan, Lange, Otto L.
core +2 more sources