Results 71 to 80 of about 2,985,939 (292)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Retinal physiology: Adapting to the changing scene [PDF]

Current Biology, 1997
The retina needs to process visual information under a wide range of conditions, a feat facilitated by gain controls. Recent results have provided new insights into one such gain control, which enables the retina to adapt to wide variations in the level of contrast in the visual scene.
openaire   +3 more sources

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Molecular and genetic mechanisms of physiological adaptations in high- altitude natives Molecular and genetic mechanisms of physiological adaptations in high- altitude natives [PDF]

فصلنامه ابن سینا, 2019
Physiological properties of adaptation to chronic hypoxia can help the high-altitude natives to overcome oxygen limitations. The protective effects of high altitudes have also been confirmed in experimental studies using the hypobaric chamber.
Abolfazl Khademi, Zahra Jahanbakhsh, Mitra Yousefpour, Afsaneh Karami Juyani   +3 more
doaj  

Avoid, attack or do both? Behavioral and physiological adaptations in natural enemies faced with novel hosts

BMC Evolutionary Biology, 2005
Background Confronted with well-defended, novel hosts, should an enemy invest in avoidance of these hosts (behavioral adaptation), neutralization of the defensive innovation (physiological adaptation) or both?
Brown Sam P, Vacher Corinne, Hochberg Michael E   +2 more
doaj   +1 more source

Root Growth Adaptation to Climate Change in Crops

Frontiers in Plant Science, 2020
Climate change is threatening crop productivity worldwide and new solutions to adapt crops to these environmental changes are urgently needed. Elevated temperatures driven by climate change affect developmental and physiological plant processes that ...
Julián Calleja-Cabrera, M. Boter, Luis Oñate-Sánchez, Mónica Pernas   +3 more
semanticscholar   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Physiological and biochemical changes in human spaceflights [PDF]

فصلنامه ابن سینا, 2017
At the moment, a variety of disasters including climate changes and meteorite fall threaten human society on the earth. So, scientists believe that it is important to explore viable alternative planets in the Solar System to ensure survival of the human ...
M Panjehpour, A Ghasemi
doaj  

Physiological Adaptions to Acute Hypoxia

, 2022
When tissues are insufficiently supplied with oxygen, the environment is said to be hypoxic. Acute (exposures to) hypoxia can occur occupationally, within the scope of training and competitions or under pathological conditions. The increasing interest in acute exposure to altitude for training and research purposes makes it more important than ever to ...
openaire   +4 more sources

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, EarlyView.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source