Results 81 to 90 of about 2,985,939 (292)

Physiologic adaptations of the tubuloglomerular feedback system

Kidney International, 1990
Knowledge of the existence of a tubuloglomerular feedback system has been available for many years. Only recently, however, have tenable hypotheses and supporting experimental data become available which have served to provide details regarding the complex inner workings of this system. The facility for examining this integrated physiologic network has
Orjan W. Peterson, Francis B. Gabbai, Scott C. Thomson, Roland C. Blantz   +3 more
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Physiological adaptation of modern Ukrainian preschoolers

PULS UCZELNI, 2013
Introduction: High demands of modern social environment to the child’s individual development are connected with their health decline and wide variation of individual capabilities.
Olha Fedortsiv, Nataliia Luchyshyn, Zofia Pilarska, Karolina Chilicka-Jasionowska, Donata Kurpas   +4 more
doaj  

Membrane lipid unsaturation as physiological adaptation to animal longevity

Frontiers in Physiology, 2013
The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems.
A. Naudí, M. Jové, V. Ayala, M. Portero-Otín, G. Barja, R. Pamplona   +5 more
semanticscholar   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Physiological and Genetic Basis of High-Altitude Indigenous Animals’ Adaptation to Hypoxic Environments

Animals
Adaptation is one of the fundamental characteristics of life activities; humans and animals inhabiting high altitudes are well adapted to hypobaric hypoxic environments, and studies on the mechanisms of this adaptation emerged a hundred years ago.
Pengfei Zhao, Shaobin Li, Zhaohua He, Xiong Ma   +3 more
doaj   +1 more source

Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice.

PLoS Genetics, 2019
Evolutionary adaptation to extreme environments often requires coordinated changes in multiple intersecting physiological pathways, but how such multi-trait adaptation occurs remains unresolved.
Rena M Schweizer, Jonathan P Velotta, Catherine M Ivy, Matthew R Jones, Sarah M Muir, Gideon S Bradburd, Jay F Storz, Graham R Scott, Zachary A Cheviron   +8 more
doaj   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Physiological aspects on altitudinal hypoxia adaptation

Acta Biológica Colombiana, 2002
This review describes the physiological changes found in people adapted to inter-mediate altitude hypoxi.
Joel Alberto Rojas Jaramillo
doaj  

Hypoxia and metabolic adaptation of cancer cells

Oncogenesis, 2016
Low oxygen tension (hypoxia) is a pervasive physiological and pathophysiological stimulus that metazoan organisms have contended with since they evolved from their single-celled ancestors.
Katherine L. Eales, Kate E. R. Hollinshead, D. Tennant   +2 more
semanticscholar   +1 more source