Results 101 to 110 of about 5,193,405 (369)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Existing evidence on the effects of climate variability and climate change on ungulates in North America: a systematic map

Environmental Evidence
Background Climate is an important driver of ungulate life-histories, population dynamics, and migratory behaviors. Climate conditions can directly impact ungulates via changes in the costs of thermoregulation and locomotion, or indirectly, via changes ...
Katherine C. Malpeli, Sarah C. Endyke, Sarah R. Weiskopf, Laura M. Thompson, Ciara G. Johnson, Katherine A. Kurth, Maxfield A. Carlin   +6 more
doaj   +1 more source

Influence of Neuromuscular Activity and Technical Determinants on Scull Rowing Performance

Applied Sciences
Rowing is a complex sport where technique can significantly impact performance. A better understanding of the rowers’ technique and neuromuscular activations during scull rowing, along with their impact on rowing performance, could greatly help trainers ...
Lorenzo Pitto, Geoffrey N. Ertel, Frédéric R. Simon, Gérome C. Gauchard, Guillaume Mornieux   +4 more
doaj   +1 more source

Contemporary Women’s Adaptation to Motherhood: The First 3 to 6 Weeks Postpartum [PDF]

, 2013
A better understanding of the process of adaptation to motherhood should enhance nurses’ ability to prepare women for the transition to motherhood and to provide care following childbirth.
Aber, Cynthia, Fawcett, Jacqueline, Weiss, Marianne   +2 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Finance for Climate Resilience in the Dawn of the Paris Era [PDF]

, 2016
This brief examines the gap in adaptation finance that must be bridged in order to fulfill the values of the Paris agreement, with a focus on regions such as Southeast Asia that are at particular risk from the effects of climate change. It also discusses
Gwynne Taraska, Shiva Polefka
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Estimation of Forces and Powers in Ergometer and Scull Rowing Based on Long Short-Term Memory Neural Networks

Sensors
Analyzing performance in rowing, e.g., analyzing force and power output profiles produced either on ergometer or on boat, is a priority for trainers and athletes.
Lorenzo Pitto, Frédéric R. Simon, Geoffrey N. Ertel, Gérome C. Gauchard, Guillaume Mornieux   +4 more
doaj   +1 more source

ADAPTATION OF THE MICRO-KJELDAHL METHOD FOR THE DETERMINATION OF NITROGEN IN PLANT TISSUES [PDF]

, 1936
Neil W. Stuart
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source