Results 91 to 100 of about 3,810,680 (297)

Adaptive mesh and geodesically sliced Schwarzschild spacetime in 3+1 dimensions

, 1996
We present first results obtained with a 3+1 dimensional adaptive mesh code in numerical general relativity. The adaptive mesh is used in conjunction with a standard ADM code for the evolution of a dynamically sliced Schwarzschild spacetime (geodesic ...
A. Brandt, A. Mitchell, B. Brügmann, B. Brügmann, B. Brügmann, Bernd Brügmann, C. Bona, C. Misner, D. Bernstein, E. Seidel, G. Allen, J. York, M. Alcubierre, M. Alcubierre, M. Berger, M. Choptuik, M. Choptuik, M. Shibata, P. Anninos, P. Anninos, P. Anninos, P. Anninos, T. Baumgarte, T. Nakamura, T. Newman, W. Press   +25 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Shared HLA class I and II alleles and clonally restricted public and private brain-infiltrating alpha beta T cells in a cohort of Rasmussen encephalitis surgery patients

Frontiers in Immunology, 2016
Rasmussen encephalitis (RE) is a rare pediatric neuroinflammatory disease characterized by intractable seizures and unilateral brain atrophy. T cell infiltrates in affected brain tissue, and the presence of circulating autoantibodies in some RE patients ...
Sugandha Dandekar, Hemani Wijesuriya, Tim Geiger, David Hamm, Gary W. Mathern, Geoffrey C. Owens   +5 more
doaj   +1 more source

How Adaptive Is an Adaptive Test: Are All Adaptive Tests Adaptive?

Journal of Computerized Adaptive Testing, 2019
The primary distinguishing feature of computerized adaptive testing (CAT) is that sets of items that are administered to examinees are specifically selected for each examinee during the test process. This implies that examinees who respond differently to items on a test will get different sets of test items.
Mark Reckase, Unhee Ju, Sewon Kim
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Adaptive scanning - a proposal how to scan theoretical predictions over a multi-dimensional parameter space efficiently

, 2004
A method is presented to exploit adaptive integration algorithms using importance sampling, like VEGAS, for the task of scanning theoretical predictions depending on a multi-dimensional parameter space.
Allanach, Baltz, Brein, Brein, Brein, Buras, Ellwanger, Hahn, Hahn, Hahn, Küblbeck, Lafaye, Lepage, Oliver Brein   +13 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Real-Time Controller Based on FPGA and DSP for Solar Ground Layer Adaptive Optics Prototype System at 1-m NVST

IEEE Photonics Journal, 2017
Solar ground layer adaptive optics (GLAO), containing a large field of view (FOV) wavefront sensor (WFS) and one deformable mirror (DM), can be used to reduce and stabilize the seeing effectively over a wide FOV. As the brain of the GLAO system, the real-
Lin Kong, Lei Zhu, Lanqiang Zhang, Hua Bao, Changhui Rao   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source