Results 91 to 100 of about 10,260,715 (247)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Driver behaviour with adaptive cruise control [PDF]

, 2005
This paper reports on the evaluation of adaptive cruise control (ACC) from a psychological perspective. It was anticipated that ACC would have an effect upon the psychology of driving, i.e.
Mark S. Young, Young, Mark S., Stanton, Neville A., Stanton, NA, Neville A. Stanton, Young, MS   +5 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

A decade of change: maternal mortality trends in Sudan, 2009–2019

BMC Public Health
Background Unacceptably high levels of preventable maternal deaths persist across sub-Saharan Africa. Due to limited research on maternal mortality in Sudan, a thorough examination is crucial to develop effective reduction strategies.
Sara Taha, Ahmad Izzoddeen, Amos Munywoki, Naiema Wagialla   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Adaptive Networks Safety Control

Advances in Electrical and Computer Engineering, 2007
In this paper we suggest a new approach to design of the adaptive network safety control mechanisms. This approach is based on the fuzzy logic theory and allows to formalize both quantitative and qualitative parameters of the network safety system.
MUKHIN, V., PAVLENKO, E.
doaj   +1 more source

Adaptive control via finite modelling and robust control

, 1988
This paper examines an adaptive control scheme which involves the selection of a fixed controller out of a finite collection, where each controller is robustly designed to account for the true plant being in a not necessarily small set of uncertainty ...
Anderson, B. D.O., Kosut, R. L.
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Estimate Laplacian Spectral Properties of Large-Scale Networks by Random Walks and Graph Transformation

Mathematics
For network graphs, numerous graph features are intimately linked to eigenvalues of the Laplacian matrix, such as connectivity and diameter. Thus, it is very important to solve eigenvalues of the Laplacian matrix for graphs.
Changlei Zhan, Xiangyu Li, Jie Chen
doaj   +1 more source