Results 51 to 60 of about 4,880,796 (294)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

An adaptive video stream transmission control method for wireless heterogeneous networks based on A3C

open access: yesDianxin kexue, 2020
The adaptive bit rate (ABR) algorithm has become the focus research in video transmission.However,due to the characteristics of 5G wireless heterogeneous networks,such as large fluctuation of channel bandwidth and obvious differences between different ...
Zhiqiang LUO, Wei WANG, Xiaorong ZHU
doaj   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

圆柱齿轮自适应互研的原理及其动力学模型

open access: yesJixie chuandong, 2010
The method of self-adaptive dynamic mutual-lapping of cylindrical gears is presented at the first time.Compared with the traditional lapping of gear,this method is a kind of dynamic self-adaptive meshing course,the advantages of which is easy to operate ...
王鹏晖, 魏冰阳, 杨建军
doaj  

Robust oxygen excess ratio control of PEMFC systems using adaptive dynamic programming

open access: yesEnergy Reports, 2022
To improve the power generation efficiency and cells lifetime of proton exchange membrane fuel cells, the oxygen excess ratio (OER) control problem is investigated in this paper.
Jing Zhu   +3 more
doaj   +1 more source

Using stochastic dynamic programming to support weed management decisions over a rotation [PDF]

open access: yes, 2009
This study describes a model that predicts the impact of weed management on the population dynamics of arable weeds over a rotation and presents the economic consequences.
Parsons, D. J.   +8 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Dynamic event‐triggered‐based adaptive frequency control of microgrids under cyber‐attacks via adaptive dynamic programming

open access: yesIET Renewable Power Generation
The increasing penetration of renewable energy sources (RES) and the development of the cyber‐physical microgrids (CPMs) make greater demands for frequency control of microgrids.
Zemeng Mi   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

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