Results 71 to 80 of about 4,669,208 (239)

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Dynamic Event-Triggering Surrounding Control for Multi-USVs Under FDI Attacks via Adaptive Dynamic Programming

open access: yesJournal of Marine Science and Engineering
This paper investigates the surrounding control problem of multiple unmanned surface vehicles (USVs) against false data injection (FDI) attacks and proposes a learning-based prescribed performance control (PPC) integrated with a dynamic event-triggering (
Dongwei Wang, Ying Zhang, Qing Hu
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A memetic algorithm with adaptive hill climbing strategy for dynamic optimization problems [PDF]

open access: yes, 2009
Copyright @ Springer-Verlag 2008Dynamic optimization problems challenge traditional evolutionary algorithms seriously since they, once converged, cannot adapt quickly to environmental changes. This paper investigates the application of memetic algorithms,
Wang, H   +5 more
core   +1 more source

Towards adaptable and adaptive policy-free middleware [PDF]

open access: yes, 2011
Submitted to Dependable and Adaptive Distributed Systems Track, ACM SAC 2007We believe that to fully support adaptive distributed applications, middleware must itself be adaptable, adaptive and policy-free.
Macdonald, Angus   +4 more
core   +2 more sources

Constrained deterministic policy gradient adaptive dynamic programming using projected gradient update

open access: yesSystems Science & Control Engineering
Learning controllers for nonlinear complex systems using data-driven model-free adaptive dynamic programming (ADP) algorithms is a challenging problem.
Timotei Lala
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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