Results 31 to 40 of about 114,936 (246)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Motion artifact cancellation in NIR spectroscopy using discrete Kalman filtering

BioMedical Engineering OnLine, 2010
Background As a continuation of our earlier work, we present in this study a Kalman filtering based algorithm for the elimination of motion artifacts present in Near Infrared spectroscopy (NIR) measurements.
Bunce Scott, Chitrapu Prabhakar, Izzetoglu Meltem, Onaral Banu   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Study on the Robust Filter Method of SINS/DVL Integrated Navigation Systems in a Complex Underwater Environment

Sensors
This paper proposes an improved adaptive filtering algorithm based on the Sage–Husa adaptive Kalman filtering algorithm to address the issue of measurement noise characteristics impacting the navigation accuracy in strapdown inertial navigation system ...
Tianlong Zhu, Jian Li, Kun Duan, Shouliang Sun   +3 more
doaj   +1 more source

The Kalman Filtering Blind Adaptive Multi-user Detector Based on Tracking Algorithm of Signal Subspace

Information, 2015
Multi-user detection is an effective method to reduce multiple access interference in code division multiple access (CDMA) systems. This paper discusses a signal subspace based blind adaptive multiuser detector and a Kalman filtering blind adaptive ...
Liqing Zhou, Henry Leung, Peng Xu, Guobao Ru, Quansheng Zhao, Da Xu   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Ameliorated mean adaptive median filtering algorithm [PDF]

E3S Web of Conferences, 2019
Aiming at the problem that the quality of infrared image decreases due to the large amount of random noise in the process of collection and transmission of infrared image of electrical equipment, and the accuracy of automatic detection of electrical ...
Zhang Hongming, Wang Yongping, Peng Chuang   +2 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Novel Optimal Robust Adaptive Scheme for Accurate GNSS RTK/INS Tightly Coupled Integration in Urban Environments

Remote Sensing, 2023
Modern navigation systems are inseparable from an integrated solution consisting of a global navigation satellite system (GNSS) and an inertial navigation system (INS) since they serve as an important cornerstone of national comprehensive positioning ...
Jiaji Wu, Jinguang Jiang, Chao Zhang, Yuying Li, Peihui Yan, Xiaoliang Meng   +5 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source