Results 51 to 60 of about 109,797 (269)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Bias Problem and Language Models
, 2007 We used the YFILTER filtering system for experiments on updating profiles and setting thresholds. We developed a new method of using language models for updating profiles that is more focused on picking informative/discriminative words for query. The new
In Adaptive Filtering
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Adaptive minimum error-rate filtering design: a review
, 2008 Adaptive filtering has been an enabling technology and has found ever-increasing applications in various state-of-the-art communication systems. Traditionally, adaptive filtering has been developed based on the Wiener or minimum mean square error (MMSE ...
Sheng Chen +7 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Polyphase Analysis of Subband Adaptive Filters
, 1999 In this paper, we derive a polyphase analysis to determine the optimum filters in a subband adaptive filter (SAF) system. The structure of this optimum solution deviates from the standard SAF approach and presents its best possible solution only as an ...
Weiss, Stephan +11 more
core +1 more source
Medical image enhancement using threshold decomposition driven adaptive morphological filter [PDF]
, 2008 One of the most common degradations in medical images is their poor contrast quality. This suggests the use of contrast enhancement methods as an attempt to modify the intensity distribution of the image.
Mahmoud, Tarek A. +4 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On the Optimality of Subband Adaptive Filtering
, 1999 In this paper, we derive a polyphase analysis to determine the optimum filters in a subband adaptive filter (SAF) system. The structure of this optimum solution deviates from the standard SAF approach and presents its best possible solution only as an ...
Weiss, S, Stewart, R W
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