Results 61 to 70 of about 109,797 (269)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Theoretical enhancement of the Gaussian filtering of engineering surfaces [PDF]
, 2013 This study is an extension of the current use of Gaussian filters to smooth surface texture waveforms. It suggests an extension using Hermite polynomials to improve the definition of boundary lines and edges in the geometry of structured surfaces, and to
Whitehouse, D. J. (David J.)
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Adaptive Filtering for Multi-Track Audio Based on Time–Frequency Masking Detection
There is a growing need to facilitate the production of recorded music as independent musicians are now key in preserving the broader cultural roles of music.
Wenhan Zhao +3 more
core +1 more source
Dental drill noise reduction using a combination of active noise control, passive noise control and adaptive filtering [PDF]
, 2007 Dental drills produce a characteristic high frequency, narrow band noise that is uncomfortable for patients and is also known to be harmful to dentists under prolonged exposure. It is therefore desirable to protect the patient and dentist whilst allowing
Kaymak, E +3 more
core
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Measuring Performance Limits of Subband Adaptive Systems
, 1998 We discuss a method to measure the convergence limits of general subband adaptive systems due to non-ideal filter banks. Aliasing caused in such filter banks presents a distortion to the subband adaptive system which forms a lower limit for the minimum ...
S. Weiss +15 more
core +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source