Results 61 to 70 of about 310,626 (286)

A novel variational Bayesian adaptive Kalman filter with mismatched process noise covariance matrix

IET Radar, Sonar & Navigation, 2023
This paper proposes a novel variational Bayesian (VB) adaptive Kalman filter with mismatched process noise covariance matrix (PNCM). Firstly, this paper explains the reason why the predicted error covariance matrix (PECM) is chosen for variational ...
Xinrui Liu, Hong Xu, Daikun Zheng, Yinghui Quan   +3 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Robust adaptive cubature Kalman filter for tracking manoeuvring target by wireless sensor network under noisy environment

IET Radar, Sonar & Navigation, 2023
The existing adaptive Kalman filters for tracking manoeuvring targets by wireless sensor networks can easily lose robustness when both the measurement and process noises are unknown and time‐varying, resulting in large positioning errors.
Xuming Fang, Dandan Huang
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Adaptive design of nano-scale dielectric structures for photonics

, 2003
Using adaptive algorithms, the design of nano-scale dielectric structures for photonic applications is explored. Widths of dielectric layers in a linear array are adjusted to match target responses of optical transmission as a function of energy.
A. F. J. Levi, Omid Nohadani, Rong Yu, Skorobogatiy M., Stephan Haas, Weifei Li, Yu Chen   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Temporal convex combination‐based secure distributed estimation against cyberattacks and noisy input

Electronics Letters
This paper proposes a new secure distributed estimation for cyber‐physical systems against adversarial attacks with noisy input. To mitigate the effect of attacks, a novel distributed attack detection based on a reliable reference estimation obtained by ...
Zhanxi Zhang, Lijuan Jia, Senran Peng, Zi‐Jiang Yang, Ran Tao   +4 more
doaj   +1 more source