Results 101 to 110 of about 4,855,871 (373)

Two novel immunization strategies for epidemic control in directed scale-free networks with nonlinear infectivity [PDF]

arXiv, 2018
In this paper, we propose two novel immunization strategies, i.e., combined immunization and duplex immunization, for SIS model in directed scale-free networks, and obtain the epidemic thresholds for them with linear and nonlinear infectivities. With the suggested two new strategies, the epidemic thresholds after immunization are greatly increased. For
arxiv  

Immune checkpoint therapy modeling of PD-1/PD-L1 blockades reveals subtle difference in their response dynamics and potential synergy in combination [PDF]

arXiv, 2021
Immune checkpoint therapy is one of the most promising immunotherapeutic methods that are likely able to give rise to durable treatment response for various cancer types. Despite much progress in the past decade, there are still critical open questions with particular regards to quantifying and predicting the efficacy of treatment and potential optimal
arxiv  

IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.

, 2013
Susceptibility to progressive infection with the fungus Cryptococcus neoformans is associated with an allergic pattern of lung inflammation, yet the factors that govern this host response are not clearly understood.
Duerr, Claudia U, Flaczyk, Adam, Fritz, Jörg H, Lafferty, Erin I, Qureshi, Salman T, Shourian, Mitra   +5 more
core   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

RELATIONSHIP BETWEEN THE INNATE AND ADAPTIVE IMMUNITY IN INFECTIONS (REVISION OF CLASSIC DOGMA)

Инфекция и иммунитет, 2014
. The mechanisms of the immune system responding to an infection depend on a complex interrelation between the elements of innate and adaptive immunity. The current understanding of how signaling from innate immunity receptors shapes the adaptive immune ...
I. S. Freidlin
doaj   +1 more source

Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]

, 2017
Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Acevedo-Acevedo, O., Bueno, S.M., Canedo-Marroquín, G., Kalergis, A.M., Lay, M.K., Rey-Jurado, E., Riedel, C.A., Saavedra, J.M.   +7 more
core   +1 more source

Human natural killer cells mediate adaptive immunity to viral antigens

Science immunology, 2019
Vaccination or childhood infection elicits antigen-specific, long-lived immunological memory in human natural killer cells. Recall responses by human NK cells One of the traditional dividing lines separating innate and adaptive immunity was the ...
Rana Nikzad, L. S. Angelo, Kevin Aviles-Padilla, D. Le, V. Singh, Lynn Bimler, M. Vukmanovic‐Stejic, Elena Vendrame, T. Ranganath, L. Simpson, N. Haigwood, C. Blish, A. Akbar, S. Paust   +13 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Scale-free dynamics of somatic adaptability in immune system [PDF]

arXiv, 2009
The long-time dynamics of somatic adaptability in immune system is simulated by a simple physical model. The immune system described by the model exhibits a scale free behavior as is observed in living systems. The balance between the positive and negative feedbacks of the model leads to a robust immune system where the positive one corresponds to the ...
arxiv  

The IFITM protein family in adaptive immunity

Immunology, 2019
Interferon‐inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses.
Diana C. Yánez, Susan Ross, T. Crompton
semanticscholar   +1 more source