Results 111 to 120 of about 312,631 (303)

VDJdb: a curated database of T-cell receptors with known antigen specificity [PDF]

, 2017
<p><strong>DISCLAIMER You are free to use VDJdb in research studies for the purpose of RepSeq sample and T-cell clonotype list annotation.
Adaptive Immunity Group
core   +1 more source

Aberrant adaptive immune response underlies genetic susceptibility to tuberculosis

Frontiers in Immunology
Mycobacterium tuberculosis (Mtb) remains a major threat worldwide, although only a fraction of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple genetic factors, and we performed comparative immunological analysis ...
Anastasiia Tsareva, Pavel V. Shelyakin, Pavel V. Shelyakin, Irina A. Shagina, Irina A. Shagina, Mikhail Yu. Myshkin, Ekaterina M. Merzlyak, Ekaterina M. Merzlyak, Valeriia V. Kriukova, Alexander S. Apt, Irina A. Linge, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova   +17 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Adaptive immunity-driven inflammation and cardiovascular disease [PDF]

, 2019
The adaptive immune response has recently emerged as an important factor in a wide variety of cardiovascular disorders including atherosclerosis, hypertension, cardiac remodeling, and heart failure; however, its role is not fully understood.
Halade, Ganesh V., Ilatovskaya, Daria V., Ganesh V. Halade, Kristine Y. DeLeon-Pennell, DeLeon-Pennell, Kristine Y., Daria V. Ilatovskaya   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Role of Innate APOBEC3G and Adaptive AID Immune Responses in HLA-HIV/SIV Immunized SHIV Infected Macaques [PDF]

, 2012
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Wang, Yufei, Singh Mahavir, Schøller, Jørgen, David Montefiori, Bunnik, Evelien M, Montefiori, D, Vaughan Robert, Mahavir Singh, Jørgen Schøller, Singh, Mahavir, Bergmeier, LA, Whittall, T, Thomas Lehner (171103), Rahman Durdana, Mahavir Singh (70735), Durdana Rahman (171080), Scholler, J, Vaughan, Robert, Rahman, D, Vaughan, R, Singh, M, Whittall Trevor, Bunnik Evelien M., Robert Vaughan, Thomas Lehner, Lesley A. Bergmeier (171089), Rahman, Durdana, Montefiori, David, Yufei Wang (171069), Evelien M. Bunnik (125512), Bergmeier, Lesley A., Whittall, Trevor, Lehner, T, Schøller Jørgen, Lehner Thomas, Hanneke Schuitemaker, Yufei Wang, Bergmeier, Lesley A, Lehner, Thomas, Lesley A Bergmeier, Schuitemaker, Hanneke, Montefiori David, Schuitemaker, H, Schuitemaker Hanneke, Bunnik, Evelien M., Trevor Whittall (171074), Trevor Whittall, Hanneke Schuitemaker (85702), David Montefiori (161606), Wang, Y, Robert Vaughan (5968), Jørgen Schøller (143988), Wang Yufei, Bergmeier Lesley A., Durdana Rahman, Bunnik, EM, Evelien M Bunnik   +56 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Complement as a regulator of adaptive immunity [PDF]

, 2017
International audienceThe complement system is an ancient and evolutionarily conserved effector system comprising in mammals over 50 circulating and membrane bound proteins.
Dirk Sieger, Killick, Justin, Gregoire Morisse, Astier, Anne, Anne L. Astier, Sieger, Dirk, Justin Killick, Morisse, Gregoire   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source