Results 231 to 240 of about 5,085,110 (360)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues. [PDF]

Immunol Rev
Olson EC, Williams A, Eisenbarth SC.
europepmc   +1 more source

Highly Sensitive Electrochemical Biosensor Based on Hairy Particles with Controllable High Enzyme Loading and Activity

Advanced Functional Materials, EarlyView.
For the first time, a highly sensitive electrochemical biosensor based on SiO2‐based hairy particles with a grafted PDMAEMA polymer brush containing a quantifiable and large amount of immobilized Laccase is reported. The fabricated biosensor exhibits a sensitivity of 0.14 A·m⁻¹, a limit of detection (LOD) of 0.1 µm, and a detection range of 0.3–750 µm,
Pavel Milkin, Anila Antony, Hongtao Cai, Antonia Debevc, Ceyda Topal, Anne Linhardt, Alla Synytska, Leonid Ionov   +7 more
wiley   +1 more source

Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy [PDF]

Jing Liu, Xiaomin Jiang, Youyou Li, Kaiting Yang, Ralph R. Weichselbaum, Wenbin Lin   +5 more
openalex   +1 more source

Data from SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer

, 2023
Shweta Joshi, Alok R. Singh, Kevin X. Liu, Timothy V. Pham, Muamera Zulcic, Dylan Skola, Hyun Bae Chun, Christopher K. Glass, Guillermo Morales, Joseph R. Garlich, Donald L. Durden   +10 more
openalex   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Peripheral-central immune interactions in Parkinson's disease: insights into innate and adaptive immunity. [PDF]

Front Mol Neurosci
Tumpa JJ, Hayder QUA, Maisa NS, Islam MN.   +3 more
europepmc   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Fundamental and emerging insights into innate and adaptive immunity in inflammatory bowel diseases. [PDF]

Front Immunol
Monteleone G, Calisi C, Salvatori S, Marafini I.   +3 more
europepmc   +1 more source

Early disruption of the innate-adaptive immune axis in vivo after infection with virulent Georgia 2007/1 ASFV

Tng, Priscilla Y. L., Al-Adwani, Laila, Goatley, Lynnette, Portugal, Raquel, Rathakrishnan, Anusyah, Netherton, Christopher L   +5 more
openalex   +1 more source