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THE EVOLUTION OF ADAPTIVE IMMUNITY
Annual Review of Immunology, 2006Approximately 500 mya two types of recombinatorial adaptive immune systems appeared in vertebrates. Jawed vertebrates generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish assemble their variable lymphocyte receptors through recombinatorial usage of ...
Zeev, Pancer, Max D, Cooper
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Critical Reviews™ in Immunology, 2011
Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, which stresses the importance of coincident whole ...
Clifford, Liongue +2 more
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Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, which stresses the importance of coincident whole ...
Clifford, Liongue +2 more
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Adaptive innate immunity or innate adaptive immunity?
Clinical Science, 2019AbstractThe innate immunity is frequently accepted as a first line of relatively primitive defense interfering with the pathogen invasion until the mechanisms of ‘privileged’ adaptive immunity with the production of antibodies and activation of cytotoxic lymphocytes ‘steal the show’.
Jan Černý, Ilja Stříž
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Temperature and adaptive immunity
2018The adaptive immune response has evolved over hundreds of millions of years to have exquisitely specific and durable mechanisms to eliminate pathogenic threats wherever they may occur in the body. Temperature has long been known to influence the response to infections, injuries, and even cancer; however, the mechanistic basis of these effects has only ...
Michelle M, Appenheimer, Sharon S, Evans
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Evolution of adaptive immunity
Biology Bulletin, 2009The current state of the problem of emergence and evolution of adaptive immunity in different taxonomic groups of animals is analyzed. Special attention is given to the emergence and phylogenetic development of the lymphocyte, the key component of immune response, as well as to the evolutionary development of T- and B-cell immune systems, adaptive ...
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Proceedings of International Conference on Neural Networks (ICNN'97), 2002
Immunized computational systems combine a priori knowledge with the adapting capabilities of immune systems to provide a powerful alternative to currently available techniques for intelligent control. In this paper, we present our perspective on various levels of intelligent control and relate them to similar functioning in human immune systems.
K. Krishnakumar, James C. Neidhoefer
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Immunized computational systems combine a priori knowledge with the adapting capabilities of immune systems to provide a powerful alternative to currently available techniques for intelligent control. In this paper, we present our perspective on various levels of intelligent control and relate them to similar functioning in human immune systems.
K. Krishnakumar, James C. Neidhoefer
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The Adaptation Model of Immunity
Immunotherapy, 2013Although 'self-nonself' and 'danger' theories have improved our understanding of the immune system, successful immunotherapy of cancer and many autoimmune diseases still remain far from reach. This indicates that our knowledge of how the immune system decides to respond effectively or ineffectively is limited.
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Adaptive immunity to mycobacteria
Current Opinion in Microbiology, 2004Advances are now being made in terms of understanding both the initiation of the adaptive or acquired response to tuberculosis infection and its interface with elements of the innate response, as well as much later events in terms of the chronic disease state where reactivation can potentially occur.
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Adaptive Immunity in Immunothrombosis
Seminars in Thrombosis and HemostasisAbstract Thrombosis is a comorbidity associated with autoimmune, allergic, and infectious conditions; however, the mechanistic basis for this elevated risk is poorly understood. The simultaneous activation of the immune and coagulation systems to assist in response to injury and efficient pathogen clearance, termed immunothrombosis ...
David Noone +2 more
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The Evolution of Adaptive Immunity
2012The concept of adaptive immunity suggests de novo generation in each individual of extremely large repertoires of diversified receptors and selective expansion of receptors that match the antigen/pathogen. Accordingly, adaptive immune system is also called "anticipatory".
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