Results 261 to 270 of about 312,631 (303)
Some of the next articles are maybe not open access.
THE EVOLUTION OF ADAPTIVE IMMUNITY
Annual Review of Immunology, 2006Approximately 500 mya two types of recombinatorial adaptive immune systems appeared in vertebrates. Jawed vertebrates generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish assemble their variable lymphocyte receptors through recombinatorial usage of ...
Zeev, Pancer, Max D, Cooper
openaire +2 more sources
Critical Reviews™ in Immunology, 2011
Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, which stresses the importance of coincident whole ...
Clifford, Liongue +2 more
openaire +2 more sources
Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, which stresses the importance of coincident whole ...
Clifford, Liongue +2 more
openaire +2 more sources
Evolution of adaptive immunity
Biology Bulletin, 2009The current state of the problem of emergence and evolution of adaptive immunity in different taxonomic groups of animals is analyzed. Special attention is given to the emergence and phylogenetic development of the lymphocyte, the key component of immune response, as well as to the evolutionary development of T- and B-cell immune systems, adaptive ...
openaire +2 more sources
Temperature and adaptive immunity
2018The adaptive immune response has evolved over hundreds of millions of years to have exquisitely specific and durable mechanisms to eliminate pathogenic threats wherever they may occur in the body. Temperature has long been known to influence the response to infections, injuries, and even cancer; however, the mechanistic basis of these effects has only ...
Michelle M, Appenheimer, Sharon S, Evans
openaire +2 more sources
The Adaptation Model of Immunity
Immunotherapy, 2013Although 'self-nonself' and 'danger' theories have improved our understanding of the immune system, successful immunotherapy of cancer and many autoimmune diseases still remain far from reach. This indicates that our knowledge of how the immune system decides to respond effectively or ineffectively is limited.
openaire +2 more sources
Adaptive immunity to mycobacteria
Current Opinion in Microbiology, 2004Advances are now being made in terms of understanding both the initiation of the adaptive or acquired response to tuberculosis infection and its interface with elements of the innate response, as well as much later events in terms of the chronic disease state where reactivation can potentially occur.
openaire +2 more sources
The Evolution of Adaptive Immunity
2012The concept of adaptive immunity suggests de novo generation in each individual of extremely large repertoires of diversified receptors and selective expansion of receptors that match the antigen/pathogen. Accordingly, adaptive immune system is also called "anticipatory".
openaire +2 more sources
Adaptive Immunity in Immunothrombosis
Seminars in Thrombosis and HemostasisAbstract Thrombosis is a comorbidity associated with autoimmune, allergic, and infectious conditions; however, the mechanistic basis for this elevated risk is poorly understood. The simultaneous activation of the immune and coagulation systems to assist in response to injury and efficient pathogen clearance, termed immunothrombosis ...
David Noone +2 more
openaire +2 more sources
Immune mechanisms: adaptive immunity
2016The role of adaptive immunity (i.e. the involvement of B and T lymphocytes) in the pathogenesis of axial spondyloarthritis has been investigated in both human disease and relevant animal models. Studies of B cell responses have not generally implicated an autoantibody in the disease, but there are abnormalities of antibody responses, particularly ...
Maxime Breban, Hill Gaston
openaire +1 more source
2016
Adaptive immunity develops during the lifetime of an organism as an adaptation to infection with certain pathogens, also referring to as the acquired immunity. Adaptive immune response is highly antigen specific, although it is relatively slow, it is highly efficient at antigen clearance, and therefore it is also termed as specific immunity.
Haoyu Sun, Cheng Sun, Zhigang Tian
openaire +1 more source
Adaptive immunity develops during the lifetime of an organism as an adaptation to infection with certain pathogens, also referring to as the acquired immunity. Adaptive immune response is highly antigen specific, although it is relatively slow, it is highly efficient at antigen clearance, and therefore it is also termed as specific immunity.
Haoyu Sun, Cheng Sun, Zhigang Tian
openaire +1 more source