Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Understanding how T helper cells learn to coordinate effective immune responses through the lens of reinforcement learning [PDF]
Phys. Rev. Research 3, 013222 (2021), 2019 The adaptive immune system of vertebrates can detect, respond to, and memorize diverse pathogens from past experience. While the clonal selection of T helper (Th) cells is the simple and established mechanism to better recognize new pathogens, the question that still remains unexplored is how the Th cells can acquire better ways to bias the responses ...
arxiv +1 more source
In the eye of the storm: T cell behavior in the inflammatory microenvironment. [PDF]
, 2013 Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and subsequently ...
Haas, R, Marelli-Berg, F, Mauro, C
core +1 more source
Adaptive potential of hybridization among malaria vectors: Introgression at the immune locus TEP1 between Anopheles coluzzii and A. gambiae in 'Far-West' Africa [PDF]
, 2015 “Far-West” Africa is known to be a secondary contact zone between the two major malaria vectors Anopheles coluzzii and A. gambiae.We investigated gene-flow and potentially adaptive introgression between these species along a west-to-east transect in ...
Caputo, Beniamino +11 more
core +5 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism
eLifeSuppressive function of regulatory T cells (Treg) is dependent on signaling of their antigen receptors triggered by cognate self, dietary, or microbial peptides presented on MHC II.
Tatyana O Nakonechnaya +7 more
doaj +1 more source
Understanding Human Innate Immune System Dependencies using Graph Neural Networks [PDF]
arXiv, 2021 Since the rapid outbreak of Covid-19 and with no approved vaccines to date, profound research interest has emerged to understand the innate immune response to viruses. This understanding can help to inhibit virus replication, prolong adaptive immune response, accelerated virus clearance, and tissue recovery, a key milestone to propose a vaccine to ...
arxiv
MHC class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity [PDF]
, 2014 Background—Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and are important regulators of immuno-inflammatory diseases. However, their role in atherosclerosis remains elusive.
Ait-Oufella, Hafid +16 more
core +2 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Frontiers in Immunology, 2022 Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate–adaptive immune response independently.
Jiang-Hui Meng +8 more
doaj +1 more source