In the eye of the storm: T cell behavior in the inflammatory microenvironment. [PDF]
Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and subsequently ...
Haas, R, Marelli-Berg, F, Mauro, C
core +1 more source
Entanglement protection of high-dimensional states by adaptive optics
We study the potential of adaptive optics (AO) to protect entanglement of high-dimensional photonic orbital-angular-momentum (OAM) states against turbulence-induced phase distortions. We demonstrate that AO is able to reduce crosstalk among the OAM modes
Buchleitner, Andreas +4 more
core +1 more source
An Adaptive Overcurrent Coordination Scheme to Improve Relay Sensitivity and Overcome Drawbacks due to Distributed Generation in Smart Grids [PDF]
Distributed Generation (DG) brought new challenges for protection engineers since standard relay settings of traditional system may no longer function properly under increasing presence of DG.
Conde, Arturo +3 more
core +1 more source
Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Increased tolerance of Litopenaeus vannamei to white spot syndrome virus (WSSV) infection after oral application of the viral envelope protein VP28 [PDF]
It has been generally accepted that invertebrates such as shrimp do not have an adaptive immune response system comparable to that of vertebrates.
van Hulten, Mariëlle C W +2 more
core +3 more sources
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Guaranteeing the effective coordination of directional overcurrent relays (DOCRs) within microgrids (MGs) is a complex nonlinear problem due to bidirectional power flows, varying fault current levels, and the need for adaptive operation across multiple ...
León F. Serna-Montoya +4 more
doaj +1 more source
Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola +3 more
core +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source

