Results 111 to 120 of about 4,471,539 (245)

Young and Lean: Elimination of Senescent Cells Boosts Adaptive Thermogenesis [PDF]

Cell Metabolism, 2017
Thermogenesis converts the chemical energy of nutrients into heat, and this is associated to improved metabolic performance. In a previous issue of Cell Metabolism, Berry et al. (2017) reported that the progenitors of thermogenic beige adipocytes lose functionality with aging, and this process can be reversed with strategies that eliminate senescent ...
Pablo J, Fernandez-Marcos, Manuel, Serrano   +1 more
openaire   +2 more sources

Apigenin promotes remodeling of peripheral and skeletal adipocytes in response to β3-AR and TLR4 activation

Frontiers in Endocrinology
BackgroundInflammation impairs adipocyte browning and diminishes the protective role of adaptive thermogenesis against obesity and metabolic disorders.
Meshail Okla, Meshail Okla
doaj   +1 more source

Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance [PDF]

, 2005
After decades of controversies about the quantitative importance of autoregulatory adjustments in energy expenditure in weight regulation, there is now increasing recognition that even subtle variations in thermogenesis could, in dynamic systems and ...
Dulloo, Abdul G., Seydoux, Josiane, Jacquet, Jean   +2 more
core  

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Redox control of non-shivering thermogenesis

Molecular Metabolism, 2019
Background: Thermogenic adipocytes reorganize their metabolism during cold exposure. Metabolic reprogramming requires readily available bioenergetics substrates, such as glucose and fatty acids, to increase mitochondrial respiration and produce heat via ...
Daniele Lettieri-Barbato
doaj   +1 more source

Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance

Biochemical Journal, 2016
Obesity and its related disorders are among the most pervasive diseases in contemporary societies, and there is an urgent need for new therapies and preventive approaches. Given (i) our poor social capacity to correct unhealthy habits, and (ii) our evolutionarily genetic predisposition to store excess energy as fat, the current environment of caloric ...
R. Lage, J. Ferno, R. Nogueiras, C. Dieguez, M. Lopez   +4 more
openaire   +3 more sources

Seasonal Dynamics of Community and Function of Gut Microbiome in Taihangshan Macaque (Macaca mulatta tcheliensis): Inferred From Metagenomic Data

Integrative Zoology, EarlyView.
A total of 435 non‐redundant metagenome‐assembled genomes (MAGs) were obtained from fecal samples of Taihangshan macaque across all four seasons. The alpha diversity of the gut microbiome in spring and winter was significantly higher than in summer and autumn. Furthermore, marked differences were detected in functional pathways and carbohydrate enzymes
Yanyan Zhou, Qi Shao, Chunbo Liu, Jundong Tian, Xiaowen Guan, Xi Zhang, Jiqi Lu   +6 more
wiley   +1 more source

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

Nature Medicine, 2017
Adaptive thermogenesis is the process of heat generation in response to cold stimulation. It is under the control of the sympathetic nervous system, whose chief effector is the catecholamine norepinephrine (NE).
K. Fischer, Henry H. Ruiz, Kevin Jhun, Brian Finan, D. Oberlin, Verena van der Heide, Anastasia V. Kalinovich, N. Petrovic, Yochai Wolf, Christoffer Clemmensen, Andrew C. Shin, Senad Divanovic, F. Brombacher, E. Glasmacher, S. Keipert, M. Jastroch, J. Nagler, K. Schramm, D. Medříková, G. Colldén, S. C. Woods, S. Herzig, D. Homann, Steffen Jung, J. Nedergaard, B. Cannon, M. Tschöp, T. Müller, C. Buettner   +28 more
semanticscholar   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source