Results 71 to 80 of about 27,279 (252)

Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).

, 1994
Udgivelsesdato: 1994-Jul-15Abnormalities due to chromosomal aberration or point mutation in gene products of growth factor receptors or in ras gene products, which lie on the same signaling pathway, can cause disease in animals and humans.
G. Pelicci, Kastury, K, Cannizzaro, L, Huebner, K, P.G. Pelicci, Lanfrancone, L, S.-H. Park, L. Cannizzaro, K. Huebner, A.E. Salcini, L. Lanfrancone, E. Lowenstein, Pelicci, G, Lowenstein, E, Druck, T, Park, S H, K. Kastury, Salcini, A E, J. Schlessinger, Li, W, T. Druck, W. Li   +21 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Studying fibroblast growth factor (FGF) mediated cell migration in "Drosophila" larval air sacs [PDF]

, 2005
Invertebrates and vertebrates use FGF signaling in many developmental processes. Mesoderm formation, limb outgrowth but also the development of the vascular system and the lung rely on FGF ligands.
Cabernard, Clemens
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The role of adaptor protein Mal/TIRAP in transducing TLR signalling

Toll-like receptor 4 (TLR4) plays an essential role in the innate immune system, protecting the body from gram-negative bacteria. However, while TLR4 activation is essential for host defence, it can also drive harmful inflammatory responses, contributing to conditions such as sepsis. Understanding the precise molecular mechanisms of the TLR4 signalling
openaire   +1 more source

RGS proteins and G protein signalling [PDF]

The work within this thesis is concerned with the creation of a temperature-sensitive Schizosaccharomyces pombe marker protein, and the regulation of the pheromone communication system of Sz. pombe reporter strains by RGS proteins.
Pateman, Cassandra Sophie Catherine
core  

Phosphorylation of the proline-rich domain of Xp95 modulates Xp95 interaction with partner proteins

, 2007
The mammalian adaptor protein Alix [ALG-2 (apoptosis-linked-gene-2 product)-interacting protein X] belongs to a conserved family of proteins that have in common an N-terminal Bro1 domain and a C-terminal PRD (proline-rich domain), both of which mediate ...
Pan, Shujuan, Clark, Richard B, Dejournett, Robert E, Kobayashi, Ryuji, Bögler, Oliver, Etkin, Laurence D, Kuang, Jian, Wu, Chuanfen   +7 more
core   +1 more source

Physical and functional interactions between STAP-2/BKS and STAT5. [PDF]

, 2005
Signal-transducing adaptor protein family of proteins (STAPs), which currently contains two members, are proposed to be adaptor molecules because of their pleckstrin homology (PH) and Src-homology 2 (SH2)-like domains.
Sekine, Yuichi, Matsuda, Tadashi, Minoguchi, Mayu, Yamamoto, Tetsuya, Yumioka, Taro, Yoshimura, Akihiko, Sugiyama, Kenji, Tsuji, Satoshi, Shimoda, Kazuya, Oritani, Kenji   +9 more
core   +1 more source